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The role of ciliary trafficking in Hedgehog receptor signaling

Defects in the biogenesis of or transport through primary cilia affect Hedgehog protein signaling, and many Hedgehog pathway components traffic through or accumulate in cilia. The Hedgehog receptor, Patched, negatively regulates the activity and ciliary accumulation of Smoothened, a seven transmembr...

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Detalles Bibliográficos
Publicado en:Sci Signal
Main Authors: Kim, Jynho, Hsia, Elaine Y. C., Brigui, Amira, Plessis, Anne, Beachy, Philip A., Zheng, Xiaoyan
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863716/
https://ncbi.nlm.nih.gov/pubmed/26038600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa5622
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