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The role of ciliary trafficking in Hedgehog receptor signaling

Defects in the biogenesis of or transport through primary cilia affect Hedgehog protein signaling, and many Hedgehog pathway components traffic through or accumulate in cilia. The Hedgehog receptor, Patched, negatively regulates the activity and ciliary accumulation of Smoothened, a seven transmembr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Signal
Hauptverfasser: Kim, Jynho, Hsia, Elaine Y. C., Brigui, Amira, Plessis, Anne, Beachy, Philip A., Zheng, Xiaoyan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4863716/
https://ncbi.nlm.nih.gov/pubmed/26038600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa5622
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