Microclusters as T Cell Signaling Hubs: Structure, Kinetics, and Regulation

Autor Balagopalan, Lakshmi, Raychaudhuri, Kumarkrishna, Samelson, Lawrence E.
Vydáno v Front Cell Dev Biol (2021)

Endocytic events in TCR signaling: focus on adapters in microclusters

Autor Balagopalan, Lakshmi, Barr, Valarie A., Samelson, Lawrence E.
Vydáno 2009

Imaging techniques for assaying lymphocyte activation in action

Autor Balagopalan, Lakshmi, Sherman, Eilon, Barr, Valarie A., Samelson, Lawrence E.
Vydáno 2011

Cytoskeletal forces during signaling activation in Jurkat T-cells

Autor Hui, King Lam, Balagopalan, Lakshmi, Samelson, Lawrence E., Upadhyaya, Arpita
Vydáno v Mol Biol Cell (2015)

The CDM Superfamily Protein MBC Directs Myoblast Fusion through a Mechanism That Requires Phosphatidylinositol 3,4,5-Triphosphate Binding but Is Independent of Direct Interaction w...

Autor Balagopalan, Lakshmi, Chen, Mei-Hui, Geisbrecht, Erika R., Abmayr, Susan M.
Vydáno 2006

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

Autor Balagopalan, Lakshmi, Coussens, Nathan P., Sherman, Eilon, Samelson, Lawrence E., Sommers, Connie L.
Vydáno 2010

TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps

Autor Yi, Jason, Balagopalan, Lakshmi, Nguyen, Tiffany, McIntire, Katherine M., Samelson, Lawrence E.
Vydáno v Nat Commun (2019)

Cell surface LAT is recruited to microclusters and is active in signaling

Autor Balagopalan, Lakshmi, Barr, Valarie A., Kortum, Robert L., Park, Anna K., Samelson, Lawrence E.
Vydáno 2013

The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters

Autor Balagopalan, Lakshmi, Kortum, Robert L., Coussens, Nathan P., Barr, Valarie A., Samelson, Lawrence E.
Vydáno v J Biol Chem (2015)

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration

Autor Guittard, Geoffrey, Kortum, Robert L, Balagopalan, Lakshmi, Çuburu, Nicolas, Nguyen, Phan, Sommers, Connie L, Samelson, Lawrence E
Vydáno v Eur J Immunol (2015)

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation

Autor Balagopalan, Lakshmi, Yi, Jason, Nguyen, Tiffany, McIntire, Katherine M., Harned, Adam S., Narayan, Kedar, Samelson, Lawrence E.
Vydáno v Nat Commun (2018)

c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes

Autor Balagopalan, Lakshmi, Barr, Valarie A., Sommers, Connie L., Barda-Saad, Mira, Goyal, Amrita, Isakowitz, Matthew S., Samelson, Lawrence E.
Vydáno 2007

Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation

Autor Manna, Asit, Zhao, Huaying, Wada, Junya, Balagopalan, Lakshmi, Tagad, Harichandra D., Appella, Ettore, Schuck, Peter, Samelson, Lawrence E.
Vydáno v Proc Natl Acad Sci U S A (2018)

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation

Autor Balagopalan, Lakshmi, Ashwell, Benjamin A., Bernot, Kelsie M., Akpan, Itoro O., Quasba, Naeha, Barr, Valarie A., Samelson, Lawrence E.
Vydáno 2011

Bypassing ubiquitination enables LAT recycling to the cell surface and enhanced signaling in T cells

Autor Balagopalan, Lakshmi, Malik, Hiba, McIntire, Katherine M., Garvey, Joseph A., Nguyen, Tiffany, Rodriguez-Peña, Ana B., Samelson, Lawrence E.
Vydáno v PLoS One (2020)

Enhanced Function of Redirected Human T Cells Expressing Linker for Activation of T Cells That Is Resistant to Ubiquitylation

Autor Kunii, Naoki, Zhao, Yangbing, Jiang, Shuguang, Liu, Xiaojun, Scholler, John, Balagopalan, Lakshmi, Samelson, Lawrence E., Milone, Michael C., June, Carl H.
Vydáno 2013

Cish actively silences tcr signaling in CD8+ T cells to maintain tumor tolerance

Autor Palmer, Douglas, Guittard, Geoff, Franco, Zulmarie, Patel, Shashank, Klebanoff, Christopher A, Sukumar, Madhusudhanan, Eil, Robert L, Clever, David, Balagopalan, Lakshmi, Roychoudhuri, Rahul, Samelson, Larry, Restifo, Nicholas
Vydáno v J Immunother Cancer (2015)

Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor

Autor Sherman, Eilon, Barr, Valarie, Manley, Suliana, Patterson, George, Balagopalan, Lakshmi, Akpan, Itoro, Regan, Carole K., Merrill, Robert K., Sommers, Connie L., Lippincott-Schwartz, Jennifer, Samelson, Lawrence E.
Vydáno 2011

Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells

Autor Coussens, Nathan P., Hayashi, Ryo, Brown, Patrick H., Balagopalan, Lakshmi, Balbo, Andrea, Akpan, Itoro, Houtman, Jon C. D., Barr, Valarie A., Schuck, Peter, Appella, Ettore, Samelson, Lawrence E.
Vydáno 2013

Dynamic Movement of the Calcium Sensor STIM1 and the Calcium Channel Orai1 in Activated T-Cells: Puncta and Distal Caps

Autor Barr, Valarie A., Bernot, Kelsie M., Srikanth, Sonal, Gwack, Yousang, Balagopalan, Lakshmi, Regan, Carole K., Helman, Daniel J., Sommers, Connie L., Oh-hora, Masatsugu, Rao, Anjana, Samelson, Lawrence E.
Vydáno 2008