Activities of Sordarins in Experimental Models of Candidiasis, Aspergillosis, and Pneumocystosis

由 Martinez, Antonio, Aviles, Pablo, Jimenez, Elena, Caballero, Jesus, Gargallo-Viola, Domingo
出版 2000

In Vitro Pharmacodynamic Parameters of Sordarin Derivatives in Comparison with Those of Marketed Compounds against Pneumocystis carinii Isolated from Rats

由 Aviles, Pablo, Aliouat, El-Moukhtar, Martinez, Antonio, Dei-Cas, Eduardo, Herreros, Esperanza, Dujardin, Lucien, Gargallo-Viola, Domingo
出版 2000

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

由 Muñoz-Alonso, María J., Álvarez, Enrique, Guillén-Navarro, María José, Pollán, Marina, Avilés, Pablo, Galmarini, Carlos M., Muñoz, Alberto
出版 2013

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

由 Moneo, Victoria, Serelde, Beatriz G, Blanco-Aparicio, Carmen, Diaz-Uriarte, Ramon, Avilés, Pablo, Santamaría, Gemma, Tercero, Juan C, Cuevas, Carmen, Carnero, Amancio
出版 2014

Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors

由 Wang, Yannick, Wozniak, Agnieszka, Wellens, Jasmien, Gebreyohannes, Yemarshet K., Guillén, Maria Jose, Avilés, Pablo M., Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick
發表在 Transl Oncol (2020)

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

由 Galmarini, Carlos M., Martin, Maud, Bouchet, Benjamin Pierre, Guillen-Navarro, María José, Martínez-Diez, Marta, Martinez-Leal, Juan Fernando, Akhmanova, Anna, Aviles, Pablo
發表在 BMC Cancer (2018)

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models

由 Céspedes, María Virtudes, Guillén, María José, López-Casas, Pedro Pablo, Sarno, Francesca, Gallardo, Alberto, Álamo, Patricia, Cuevas, Carmen, Hidalgo, Manuel, Galmarini, Carlos María, Allavena, Paola, Avilés, Pablo, Mangues, Ramón
發表在 Dis Model Mech (2016)

CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110

由 Domínguez, Juan Manuel, Pérez-Chacón, Gema, Guillén, María José, Muñoz-Alonso, María José, Somovilla-Crespo, Beatriz, Cibrián, Danay, Acosta-Iborra, Bárbara, Adrados, Magdalena, Muñoz-Calleja, Cecilia, Cuevas, Carmen, Sánchez-Madrid, Francisco, Avilés, Pablo, Zapata, Juan M.
發表在 J Hematol Oncol (2020)

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone

由 López-Iglesias, Ana-Alicia, González-Méndez, Lorena, San-Segundo, Laura, Herrero, Ana B., Hernández-García, Susana, Martín-Sánchez, Montserrat, Gutiérrez, Norma C., Paíno, Teresa, Avilés, Pablo, Mateos, María-Victoria, San-Miguel, Jesús F., Garayoa, Mercedes, Ocio, Enrique M.
發表在 Haematologica (2017)

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response

由 Colado, Enrique, Paíno, Teresa, Maiso, Patricia, Ocio, Enrique M., Chen, Xi, Álvarez-Fernández, Stela, Gutiérrez, Norma C., Martín-Sánchez, Jesús, Flores-Montero, Juan, San Segundo, Laura, Garayoa, Mercedes, Fernández-Lázaro, Diego, Vidriales, Maria-Belen, Galmarini, Carlos M., Avilés, Pablo, Cuevas, Carmen, Pandiella, Atanasio, San-Miguel, Jesús F.
出版 2011

Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus

由 Harlow, Matt L., Maloney, Nichole, Roland, Joseph, Guillen Navarro, Maria Jose, Easton, Matthew K., Kitchen-Goosen, Susan M., Boguslawski, Elissa, Madaj, Zachary B., Johnson, Ben K., Bowman, Megan J., D’Incalci, Maurizio, Winn, Mary E., Turner, Lisa, Hostetter, Galen, Galmarini, Carlos María, Aviles, Pablo, Grohar, Patrick J.
發表在 Cancer Res (2016)

Evaluation of the Preclinical Efficacy of Lurbinectedin in Malignant Pleural Mesothelioma

由 Anobile, Dario P., Bironzo, Paolo, Picca, Francesca, Lingua, Marcello F., Morena, Deborah, Righi, Luisella, Napoli, Francesca, Papotti, Mauro G., Pittaro, Alessandra, Di Nicolantonio, Federica, Gigliotti, Chiara, Bussolino, Federico, Comunanza, Valentina, Guerrera, Francesco, Sandri, Alberto, Leo, Francesco, Libener, Roberta, Aviles, Pablo, Novello, Silvia, Taulli, Riccardo, Scagliotti, Giorgio V., Riganti, Chiara
發表在 Cancers (Basel) (2021)

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

由 Reuschl, Ann-Kathrin, Thorne, Lucy G., Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, Hiatt, Joseph, Soucheray, Margaret, Turner, Jane, Fabius, Jacqueline M., Nguyen, Gina T., Swaney, Danielle L., Rosales, Romel, White, Kris M., Avilés, Pablo, Kirby, Ilsa T., Melnyk, James E., Shi, Ying, Zhang, Ziyang, Shokat, Kevan M., García-Sastre, Adolfo, Jolly, Clare, Towers, Gregory J., Krogan, Nevan J.
發表在 bioRxiv (2021)

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

由 White, Kris M., Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B., Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M., Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M., Krogan, Nevan J., García-Sastre, Adolfo
發表在 Science (2021)

Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization

由 Varona, José F., Landete, Pedro, Lopez-Martin, Jose A., Estrada, Vicente, Paredes, Roger, Guisado-Vasco, Pablo, de Orueta, Lucía Fernández, Torralba, Miguel, Fortún, Jesús, Vates, Roberto, Barberán, José, Clotet, Bonaventura, Ancochea, Julio, Carnevali, Daniel, Cabello, Noemí, Porras, Lourdes, Gijón, Paloma, Monereo, Alfonso, Abad, Daniel, Zúñiga, Sonia, Sola, Isabel, Rodon, Jordi, Izquierdo-Useros, Nuria, Fudio, Salvador, Pontes, María José, de Rivas, Beatriz, Girón de Velasco, Patricia, Sopesén, Belén, Nieto, Antonio, Gómez, Javier, Avilés, Pablo, Lubomirov, Rubin, White, Kris M., Rosales, Romel, Yildiz, Soner, Reuschl, Ann-Kathrin, Thorne, Lucy G., Jolly, Clare, Towers, Greg J., Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, Enjuanes, Luis, Fernández-Sousa, Jose M., Krogan, Nevan J., Jimeno, José M., García-Sastre, Adolfo
發表在 medRxiv (2021)