Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors

The majority of patients with gastrointestinal stromal tumors (GIST) eventually become resistant with time due to secondary mutations in the driver receptor tyrosine kinase. Novel treatments that do not target these receptors may therefore be preferable. For the first time, we evaluated a tubulin in...

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Bibliographische Detailangaben
Veröffentlicht in:Transl Oncol
Hauptverfasser: Wang, Yannick, Wozniak, Agnieszka, Wellens, Jasmien, Gebreyohannes, Yemarshet K., Guillén, Maria Jose, Avilés, Pablo M., Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2020
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7381700/
https://ncbi.nlm.nih.gov/pubmed/32711367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2020.100832
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