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Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors

The majority of patients with gastrointestinal stromal tumors (GIST) eventually become resistant with time due to secondary mutations in the driver receptor tyrosine kinase. Novel treatments that do not target these receptors may therefore be preferable. For the first time, we evaluated a tubulin in...

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Main Authors: Yannick Wang, Agnieszka Wozniak, Jasmien Wellens, Yemarshet K. Gebreyohannes, Maria Jose Guillén, Pablo M. Avilés, Maria Debiec-Rychter, Raf Sciot, Patrick Schöffski
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-11-01
Colecção:Translational Oncology
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Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1936523320303247
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