A potent combination of the novel PI3K inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal

INTRODUCTION: Oncogenic signaling in gastrointestinal stromal tumors (GIST) is sustained via PI3K/AKT pathway. We used a panel of six GIST xenograft models to assess efficacy of GDC-0941 as single agent or in combination with imatinib (IMA). EXPERIMENTAL DESIGN: Nude mice (n=136) were grafted bilate...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Floris, Giuseppe, Wozniak, Agnieszka, Sciot, Raf, Li, Haifu, Friedman, Lori, Van Looy, Thomas, Wellens, Jasmien, Vermaelen, Peter, Deroose, Christophe M., Fletcher, Jonathan A., Debiec-Rychter, Maria, Schöffski, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405777/
https://ncbi.nlm.nih.gov/pubmed/23231951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2853
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