Activities of Sordarins in Experimental Models of Candidiasis, Aspergillosis, and Pneumocystosis

Por Martinez, Antonio, Aviles, Pablo, Jimenez, Elena, Caballero, Jesus, Gargallo-Viola, Domingo
Publicado em 2000

In Vitro Pharmacodynamic Parameters of Sordarin Derivatives in Comparison with Those of Marketed Compounds against Pneumocystis carinii Isolated from Rats

Por Aviles, Pablo, Aliouat, El-Moukhtar, Martinez, Antonio, Dei-Cas, Eduardo, Herreros, Esperanza, Dujardin, Lucien, Gargallo-Viola, Domingo
Publicado em 2000

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

Por Muñoz-Alonso, María J., Álvarez, Enrique, Guillén-Navarro, María José, Pollán, Marina, Avilés, Pablo, Galmarini, Carlos M., Muñoz, Alberto
Publicado em 2013

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

Por Moneo, Victoria, Serelde, Beatriz G, Blanco-Aparicio, Carmen, Diaz-Uriarte, Ramon, Avilés, Pablo, Santamaría, Gemma, Tercero, Juan C, Cuevas, Carmen, Carnero, Amancio
Publicado em 2014

Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors

Por Wang, Yannick, Wozniak, Agnieszka, Wellens, Jasmien, Gebreyohannes, Yemarshet K., Guillén, Maria Jose, Avilés, Pablo M., Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick
Publicado no Transl Oncol (2020)

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

Por Galmarini, Carlos M., Martin, Maud, Bouchet, Benjamin Pierre, Guillen-Navarro, María José, Martínez-Diez, Marta, Martinez-Leal, Juan Fernando, Akhmanova, Anna, Aviles, Pablo
Publicado no BMC Cancer (2018)

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models

Por Céspedes, María Virtudes, Guillén, María José, López-Casas, Pedro Pablo, Sarno, Francesca, Gallardo, Alberto, Álamo, Patricia, Cuevas, Carmen, Hidalgo, Manuel, Galmarini, Carlos María, Allavena, Paola, Avilés, Pablo, Mangues, Ramón
Publicado no Dis Model Mech (2016)

CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110

Por Domínguez, Juan Manuel, Pérez-Chacón, Gema, Guillén, María José, Muñoz-Alonso, María José, Somovilla-Crespo, Beatriz, Cibrián, Danay, Acosta-Iborra, Bárbara, Adrados, Magdalena, Muñoz-Calleja, Cecilia, Cuevas, Carmen, Sánchez-Madrid, Francisco, Avilés, Pablo, Zapata, Juan M.
Publicado no J Hematol Oncol (2020)

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone

Por López-Iglesias, Ana-Alicia, González-Méndez, Lorena, San-Segundo, Laura, Herrero, Ana B., Hernández-García, Susana, Martín-Sánchez, Montserrat, Gutiérrez, Norma C., Paíno, Teresa, Avilés, Pablo, Mateos, María-Victoria, San-Miguel, Jesús F., Garayoa, Mercedes, Ocio, Enrique M.
Publicado no Haematologica (2017)

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response

Por Colado, Enrique, Paíno, Teresa, Maiso, Patricia, Ocio, Enrique M., Chen, Xi, Álvarez-Fernández, Stela, Gutiérrez, Norma C., Martín-Sánchez, Jesús, Flores-Montero, Juan, San Segundo, Laura, Garayoa, Mercedes, Fernández-Lázaro, Diego, Vidriales, Maria-Belen, Galmarini, Carlos M., Avilés, Pablo, Cuevas, Carmen, Pandiella, Atanasio, San-Miguel, Jesús F.
Publicado em 2011

Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus

Por Harlow, Matt L., Maloney, Nichole, Roland, Joseph, Guillen Navarro, Maria Jose, Easton, Matthew K., Kitchen-Goosen, Susan M., Boguslawski, Elissa, Madaj, Zachary B., Johnson, Ben K., Bowman, Megan J., D’Incalci, Maurizio, Winn, Mary E., Turner, Lisa, Hostetter, Galen, Galmarini, Carlos María, Aviles, Pablo, Grohar, Patrick J.
Publicado no Cancer Res (2016)

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

Por Reuschl, Ann-Kathrin, Thorne, Lucy G., Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, Hiatt, Joseph, Soucheray, Margaret, Turner, Jane, Fabius, Jacqueline M., Nguyen, Gina T., Swaney, Danielle L., Rosales, Romel, White, Kris M., Avilés, Pablo, Kirby, Ilsa T., Melnyk, James E., Shi, Ying, Zhang, Ziyang, Shokat, Kevan M., García-Sastre, Adolfo, Jolly, Clare, Towers, Gregory J., Krogan, Nevan J.
Publicado no bioRxiv (2021)

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

Por White, Kris M., Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B., Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M., Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M., Krogan, Nevan J., García-Sastre, Adolfo
Publicado no Science (2021)