Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment

Por Galmarini, Carlos M., D’Incalci, Maurizio, Allavena, Paola
Publicado em 2014

Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugs

Por Galmarini, Carlos M., Warren, Galya, Senanayake, Madapathage T., Vinogradov, Serguei V.
Publicado em 2010

Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines

Por Ávila-Arroyo, Sonia, Nuñez, Gema Santamaría, García-Fernández, Luis Francisco, Galmarini, Carlos M.
Publicado no J Breast Cancer (2015)

Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines

Por Galmarini, Carlos M., Warren, Galya, Kohli, Ekta, Zeman, Arin, Mitin, Anton, Vinogradov, Serguei V.
Publicado em 2008

Temperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations

Por Bueren-Calabuig, Juan A., Giraudon, Christophe, Galmarini, Carlos M., Egly, Jean Marc, Gago, Federico
Publicado em 2011

Hypoxia Reduces the Efficiency of Elisidepsin by Inhibiting Hydroxylation and Altering the Structure of Lipid Rafts

Por Király, Anna, Váradi, Tímea, Hajdu, Tímea, Rühl, Ralph, Galmarini, Carlos M., Szöllősi, János, Nagy, Peter
Publicado em 2013

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

Por Muñoz-Alonso, María J., Álvarez, Enrique, Guillén-Navarro, María José, Pollán, Marina, Avilés, Pablo, Galmarini, Carlos M., Muñoz, Alberto
Publicado em 2013

Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway

Por Martínez, Sandra, Pérez, Laura, Galmarini, Carlos M, Aracil, Miguel, Tercero, Juan C, Gago, Federico, Albella, Beatriz, Bueren, Juan A
Publicado em 2013

Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair

Por Lima, Michelle, Bouzid, Hana, Soares, Daniele G., Selle, Frédéric, Morel, Claire, Galmarini, Carlos M., Henriques, João A. P., Larsen, Annette K., Escargueil, Alexandre E.
Publicado no Oncotarget (2016)

Expression of XPG protein in human normal and tumor tissues

Por Aracil, Miguel, Dauffenbach, Lisa M, Diez, Marta Martínez, Richeh, Rana, Moneo, Victoria, Leal, Juan Fernando Martínez, Fernández, Luis Francisco García, Kerfoot, Christopher A, Galmarini, Carlos M
Publicado em 2013

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin

Por Losada, Alejandro, Muñoz-Alonso, María José, García, Carolina, Sánchez-Murcia, Pedro A., Martínez-Leal, Juan Fernando, Domínguez, Juan Manuel, Lillo, M. Pilar, Gago, Federico, Galmarini, Carlos M.
Publicado no Sci Rep (2016)

Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death

Por Molina-Guijarro, José Manuel, García, Carolina, Macías, Álvaro, García-Fernández, Luis Francisco, Moreno, Cristina, Reyes, Fernando, Martínez-Leal, Juan Fernando, Fernández, Rogelio, Martínez, Valentín, Valenzuela, Carmen, Lillo, M. Pilar, Galmarini, Carlos M.
Publicado no PLoS One (2015)

Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

Por Molina-Guijarro, José M., Macías, Álvaro, García, Carolina, Muñoz, Eva, García-Fernández, Luis F., David, Miren, Núñez, Lucía, Martínez-Leal, Juan F., Moneo, Victoria, Cuevas, Carmen, Lillo, M. Pilar, Villalobos Jorge, Carlos, Valenzuela, Carmen, Galmarini, Carlos M.
Publicado em 2011

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response

Por Colado, Enrique, Paíno, Teresa, Maiso, Patricia, Ocio, Enrique M., Chen, Xi, Álvarez-Fernández, Stela, Gutiérrez, Norma C., Martín-Sánchez, Jesús, Flores-Montero, Juan, San Segundo, Laura, Garayoa, Mercedes, Fernández-Lázaro, Diego, Vidriales, Maria-Belen, Galmarini, Carlos M., Avilés, Pablo, Cuevas, Carmen, Pandiella, Atanasio, San-Miguel, Jesús F.
Publicado em 2011

Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms

Por Romano, Michela, Della Porta, Matteo Giovanni, Gallì, Anna, Panini, Nicolò, Licandro, Simonetta Andrea, Bello, Ezia, Craparotta, Ilaria, Rosti, Vittorio, Bonetti, Elisa, Tancredi, Richard, Rossi, Marianna, Mannarino, Laura, Marchini, Sergio, Porcu, Luca, Galmarini, Carlos M, Zambelli, Alberto, Zecca, Marco, Locatelli, Franco, Cazzola, Mario, Biondi, Andrea, Rambaldi, Alessandro, Allavena, Paola, Erba, Eugenio, D'Incalci, Maurizio
Publicado no Br J Cancer (2017)