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Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines

BACKGROUND: The therapeutic efficiency of anticancer NA strongly depends on their intracellular accumulation and conversion into 5’-triphosphates. Since active NATP cannot be directly administrated due to instability, we present here a strategy of nanoencapsulation of these active drugs for efficien...

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Autors principals: Galmarini, Carlos M., Warren, Galya, Kohli, Ekta, Zeman, Arin, Mitin, Anton, Vinogradov, Serguei V.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593126/
https://ncbi.nlm.nih.gov/pubmed/18852140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0616
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