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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
BACKGROUND: Vascular supply of tumors is one of the main targets for cancer therapy. Here, we investigated if plocabulin (PM060184), a novel marine-derived microtubule-binding agent, presents antiangiogenic and vascular-disrupting activities. METHODS: The effects of plocabulin on microtubule network...
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出版年: | BMC Cancer |
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主要な著者: | , , , , , , , |
フォーマット: | Artigo |
言語: | Inglês |
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BioMed Central
2018
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5803861/ https://ncbi.nlm.nih.gov/pubmed/29415678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4086-2 |
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