Activities of Sordarins in Experimental Models of Candidiasis, Aspergillosis, and Pneumocystosis

le Martinez, Antonio, Aviles, Pablo, Jimenez, Elena, Caballero, Jesus, Gargallo-Viola, Domingo
Foilsithe 2000

In Vitro Pharmacodynamic Parameters of Sordarin Derivatives in Comparison with Those of Marketed Compounds against Pneumocystis carinii Isolated from Rats

le Aviles, Pablo, Aliouat, El-Moukhtar, Martinez, Antonio, Dei-Cas, Eduardo, Herreros, Esperanza, Dujardin, Lucien, Gargallo-Viola, Domingo
Foilsithe 2000

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

le Muñoz-Alonso, María J., Álvarez, Enrique, Guillén-Navarro, María José, Pollán, Marina, Avilés, Pablo, Galmarini, Carlos M., Muñoz, Alberto
Foilsithe 2013

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

le Moneo, Victoria, Serelde, Beatriz G, Blanco-Aparicio, Carmen, Diaz-Uriarte, Ramon, Avilés, Pablo, Santamaría, Gemma, Tercero, Juan C, Cuevas, Carmen, Carnero, Amancio
Foilsithe 2014

Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors

le Wang, Yannick, Wozniak, Agnieszka, Wellens, Jasmien, Gebreyohannes, Yemarshet K., Guillén, Maria Jose, Avilés, Pablo M., Debiec-Rychter, Maria, Sciot, Raf, Schöffski, Patrick
Foilsithe in Transl Oncol (2020)

Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells

le Galmarini, Carlos M., Martin, Maud, Bouchet, Benjamin Pierre, Guillen-Navarro, María José, Martínez-Diez, Marta, Martinez-Leal, Juan Fernando, Akhmanova, Anna, Aviles, Pablo
Foilsithe in BMC Cancer (2018)

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models

le Céspedes, María Virtudes, Guillén, María José, López-Casas, Pedro Pablo, Sarno, Francesca, Gallardo, Alberto, Álamo, Patricia, Cuevas, Carmen, Hidalgo, Manuel, Galmarini, Carlos María, Allavena, Paola, Avilés, Pablo, Mangues, Ramón
Foilsithe in Dis Model Mech (2016)

CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110

le Domínguez, Juan Manuel, Pérez-Chacón, Gema, Guillén, María José, Muñoz-Alonso, María José, Somovilla-Crespo, Beatriz, Cibrián, Danay, Acosta-Iborra, Bárbara, Adrados, Magdalena, Muñoz-Calleja, Cecilia, Cuevas, Carmen, Sánchez-Madrid, Francisco, Avilés, Pablo, Zapata, Juan M.
Foilsithe in J Hematol Oncol (2020)

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone

le López-Iglesias, Ana-Alicia, González-Méndez, Lorena, San-Segundo, Laura, Herrero, Ana B., Hernández-García, Susana, Martín-Sánchez, Montserrat, Gutiérrez, Norma C., Paíno, Teresa, Avilés, Pablo, Mateos, María-Victoria, San-Miguel, Jesús F., Garayoa, Mercedes, Ocio, Enrique M.
Foilsithe in Haematologica (2017)

Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response

le Colado, Enrique, Paíno, Teresa, Maiso, Patricia, Ocio, Enrique M., Chen, Xi, Álvarez-Fernández, Stela, Gutiérrez, Norma C., Martín-Sánchez, Jesús, Flores-Montero, Juan, San Segundo, Laura, Garayoa, Mercedes, Fernández-Lázaro, Diego, Vidriales, Maria-Belen, Galmarini, Carlos M., Avilés, Pablo, Cuevas, Carmen, Pandiella, Atanasio, San-Miguel, Jesús F.
Foilsithe 2011

Lurbinectedin inactivates the Ewing sarcoma oncoprotein EWS-FLI1 by redistributing it within the nucleus

le Harlow, Matt L., Maloney, Nichole, Roland, Joseph, Guillen Navarro, Maria Jose, Easton, Matthew K., Kitchen-Goosen, Susan M., Boguslawski, Elissa, Madaj, Zachary B., Johnson, Ben K., Bowman, Megan J., D’Incalci, Maurizio, Winn, Mary E., Turner, Lisa, Hostetter, Galen, Galmarini, Carlos María, Aviles, Pablo, Grohar, Patrick J.
Foilsithe in Cancer Res (2016)

Evaluation of the Preclinical Efficacy of Lurbinectedin in Malignant Pleural Mesothelioma

le Anobile, Dario P., Bironzo, Paolo, Picca, Francesca, Lingua, Marcello F., Morena, Deborah, Righi, Luisella, Napoli, Francesca, Papotti, Mauro G., Pittaro, Alessandra, Di Nicolantonio, Federica, Gigliotti, Chiara, Bussolino, Federico, Comunanza, Valentina, Guerrera, Francesco, Sandri, Alberto, Leo, Francesco, Libener, Roberta, Aviles, Pablo, Novello, Silvia, Taulli, Riccardo, Scagliotti, Giorgio V., Riganti, Chiara
Foilsithe in Cancers (Basel) (2021)

Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant

le Reuschl, Ann-Kathrin, Thorne, Lucy G., Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, Hiatt, Joseph, Soucheray, Margaret, Turner, Jane, Fabius, Jacqueline M., Nguyen, Gina T., Swaney, Danielle L., Rosales, Romel, White, Kris M., Avilés, Pablo, Kirby, Ilsa T., Melnyk, James E., Shi, Ying, Zhang, Ziyang, Shokat, Kevan M., García-Sastre, Adolfo, Jolly, Clare, Towers, Gregory J., Krogan, Nevan J.
Foilsithe in bioRxiv (2021)

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A

le White, Kris M., Rosales, Romel, Yildiz, Soner, Kehrer, Thomas, Miorin, Lisa, Moreno, Elena, Jangra, Sonia, Uccellini, Melissa B., Rathnasinghe, Raveen, Coughlan, Lynda, Martinez-Romero, Carles, Batra, Jyoti, Rojc, Ajda, Bouhaddou, Mehdi, Fabius, Jacqueline M., Obernier, Kirsten, Dejosez, Marion, Guillén, María José, Losada, Alejandro, Avilés, Pablo, Schotsaert, Michael, Zwaka, Thomas, Vignuzzi, Marco, Shokat, Kevan M., Krogan, Nevan J., García-Sastre, Adolfo
Foilsithe in Science (2021)

Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization

le Varona, José F., Landete, Pedro, Lopez-Martin, Jose A., Estrada, Vicente, Paredes, Roger, Guisado-Vasco, Pablo, de Orueta, Lucía Fernández, Torralba, Miguel, Fortún, Jesús, Vates, Roberto, Barberán, José, Clotet, Bonaventura, Ancochea, Julio, Carnevali, Daniel, Cabello, Noemí, Porras, Lourdes, Gijón, Paloma, Monereo, Alfonso, Abad, Daniel, Zúñiga, Sonia, Sola, Isabel, Rodon, Jordi, Izquierdo-Useros, Nuria, Fudio, Salvador, Pontes, María José, de Rivas, Beatriz, Girón de Velasco, Patricia, Sopesén, Belén, Nieto, Antonio, Gómez, Javier, Avilés, Pablo, Lubomirov, Rubin, White, Kris M., Rosales, Romel, Yildiz, Soner, Reuschl, Ann-Kathrin, Thorne, Lucy G., Jolly, Clare, Towers, Greg J., Zuliani-Alvarez, Lorena, Bouhaddou, Mehdi, Obernier, Kirsten, Enjuanes, Luis, Fernández-Sousa, Jose M., Krogan, Nevan J., Jimeno, José M., García-Sastre, Adolfo
Foilsithe in medRxiv (2021)