Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery

Autor Brown, James R, Auger, Kurt R
Vydáno 2011

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

Autor Lai, Zhihong, Yang, Tao, Kim, Young B., Sielecki, Thais M., Diamond, Melody A., Strack, Peter, Rolfe, Mark, Caligiuri, Maureen, Benfield, Pamela A., Auger, Kurt R., Copeland, Robert A.
Vydáno 2002

A phase Ib dose-finding, pharmacokinetic study of the focal adhesion kinase inhibitor GSK2256098 and trametinib in patients with advanced solid tumours

Autor Mak, Gabriel, Soria, Jean-Charles, Blagden, Sarah P., Plummer, Ruth, Fleming, Ronald A., Nebot, Noelia, Zhang, Jianping, Mazumdar, Jolly, Rogan, Debra, Gazzah, Anas, Rizzuto, Ivana, Greystoke, Alastair, Yan, Li, Tolson, Jerry, Auger, Kurt R., Arkenau, Hendrik-Tobias
Vydáno v Br J Cancer (2019)

A study of the focal adhesion kinase inhibitor GSK2256098 in patients with recurrent glioblastoma with evaluation of tumor penetration of [(11)C]GSK2256098

Autor Brown, Nicholas F, Williams, Matthew, Arkenau, Hendrik-Tobias, Fleming, Ronald A, Tolson, Jerry, Yan, Li, Zhang, Jianping, Singh, Rajendra, Auger, Kurt R, Lenox, Laurie, Cox, David, Lewis, Yvonne, Plisson, Christophe, Searle, Graham, Saleem, Azeem, Blagden, Sarah, Mulholland, Paul
Vydáno v Neuro Oncol (2018)

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

Autor Wyce, Anastasia, Ganji, Gopinath, Smitheman, Kimberly N., Chung, Chun-wa, Korenchuk, Susan, Bai, Yuchen, Barbash, Olena, Le, BaoChau, Craggs, Peter D., McCabe, Michael T., Kennedy-Wilson, Karen M., Sanchez, Lydia V., Gosmini, Romain L., Parr, Nigel, McHugh, Charles F., Dhanak, Dashyant, Prinjha, Rab K., Auger, Kurt R., Tummino, Peter J.
Vydáno 2013

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

Autor Yang, Hongfang, Medeiros, Patricia F., Raha, Kaushik, Elkins, Patricia, Lind, Kenneth E., Lehr, Ruth, Adams, Nicholas D., Burgess, Joelle L., Schmidt, Stanley J., Knight, Steven D., Auger, Kurt R., Schaber, Michael D., Franklin, G. Joseph, Ding, Yun, DeLorey, Jennifer L., Centrella, Paolo A., Mataruse, Sibongile, Skinner, Steven R., Clark, Matthew A., Cuozzo, John W., Evindar, Ghotas
Vydáno v ACS Med Chem Lett (2015)

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Autor Dawson, Mark A., Prinjha, Rab K., Dittman, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C, Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M., Huthmacher, Carola, Gudgin, Emma, Lugo, Dave, Beinke, Soren, Chapman, Trevor D., Roberts, Emma J., Soden, Peter E, Auger, Kurt R., Mirguet, Olivier, Doehner, Konstanze, Delwel, Ruud, Burnett, Alan K., Jeffrey, Phillip, Drewes, Gerard, Lee, Kevin, Huntly, Brian J.P, Kouzarides, Tony
Vydáno 2011

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

Autor Knight, Steven D., Adams, Nicholas D., Burgess, Joelle L., Chaudhari, Amita M., Darcy, Michael G., Donatelli, Carla A., Luengo, Juan I., Newlander, Ken A., Parrish, Cynthia A., Ridgers, Lance H., Sarpong, Martha A., Schmidt, Stanley J., Van Aller, Glenn S., Carson, Jeffrey D., Diamond, Melody A., Elkins, Patricia A., Gardiner, Christine M., Garver, Eric, Gilbert, Seth A., Gontarek, Richard R., Jackson, Jeffrey R., Kershner, Kevin L., Luo, Lusong, Raha, Kaushik, Sherk, Christian S., Sung, Chiu-Mei, Sutton, David, Tummino, Peter J., Wegrzyn, Ronald J., Auger, Kurt R., Dhanak, Dashyant
Vydáno 2010

Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295

Autor Qian, Xiangping, McDonald, Andrew, Zhou, Han-Jie, Adams, Nicholas D., Parrish, Cynthia A., Duffy, Kevin J., Fitch, Duke M., Tedesco, Rosanna, Ashcraft, Luke W., Yao, Bing, Jiang, Hong, Huang, Jennifer K., Marin, Melchor V., Aroyan, Carrie E., Wang, Jianchao, Ahmed, Seyed, Burgess, Joelle L., Chaudhari, Amita M., Donatelli, Carla A., Darcy, Michael G., Ridgers, Lance H., Newlander, Ken A., Schmidt, Stanley J., Chai, Deping, Colón, Mariela, Zimmerman, Michael N., Lad, Latesh, Sakowicz, Roman, Schauer, Stephen, Belmont, Lisa, Baliga, Ramesh, Pierce, Daniel W., Finer, Jeffrey T., Wang, Zhengping, Morgan, Bradley P., Morgans, David J., Auger, Kurt R., Sung, Chiu-Mei, Carson, Jeff D., Luo, Lusong, Hugger, Erin D., Copeland, Robert A., Sutton, David, Elliott, John D., Jackson, Jeffrey R., Wood, Kenneth W., Dhanak, Dashyant, Bergnes, Gustave, Knight, Steven D.
Vydáno 2010