Improving cancer chemotherapy with modulators of ABC drug transporters

Por Shukla, S., Ohnuma, S., Ambudkar, S. V.
Publicado em 2011

The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters

Por Golin, John, Ambudkar, Suresh V.
Publicado no Biochem J (2015)

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

Por Sauna, Zuben E., Ambudkar, Suresh V.
Publicado em 2000

Analysis of Expression of Drug Resistance-Linked ABC Transporters in Cancer Cells by Quantitative RT-PCR

Por Calcagno, Anna Maria, Ambudkar, Suresh V.
Publicado em 2010

The molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells

Por Calcagno, Anna Maria, Ambudkar, Suresh V.
Publicado em 2010

Variable stoichiometry of phosphate-linked anion exchange in Streptococcus lactis: implications for the mechanism of sugar phosphate transport by bacteria.

Por Ambudkar, S V, Sonna, L A, Maloney, P C
Publicado em 1986

Discovering Natural Product Modulators to Overcome Multidrug Resistance in Cancer Chemotherapy

Por Wu, Chung-Pu, Ohnuma, Shinobu, Ambudkar, Suresh V.
Publicado em 2011

Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance

Por Shukla, Suneet, Chen, Zhe-Sheng, Ambudkar, Suresh V.
Publicado em 2012

Structure of a multidrug transporter: Crystal structures of a mammalian multidrug efflux pump bound to peptide inhibitors may reveal drug binding sites

Por Gottesman, Michael M., Ambudkar, Suresh V., Xia, Di
Publicado em 2009

Drug-Protein Hydrogen Bonds Govern the Inhibition of the ATP Hydrolysis of the Multidrug Transporter P-glycoprotein

Por Chufan, Eduardo E., Kapoor, Khyati, Ambudkar, Suresh V.
Publicado no Biochem Pharmacol (2015)

Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and...

Por Vahedi, Shahrooz, Chufan, Eduardo E., Ambudkar, Suresh V.
Publicado no Biochem Pharmacol (2017)

Phosphate/hexose 6-phosphate antiport in Streptococcus lactis.

Por Maloney, P C, Ambudkar, S V, Thomas, J, Schiller, L
Publicado em 1984

Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: Evaluation of current strategies

Por Wu, Chung-Pu, Calcagno, Anna Maria, Ambudkar, Suresh V.
Publicado em 2008

Biochemical Mechanism of Modulation of Human P-glycoprotein by Stemofoline

Por Chanmahasathien, Wisinee, Ohnuma, Shinobu, Ambudkar, Suresh V., Limtrakul, Pornngarm
Publicado em 2011

The naphthoquinones, vitamin K3 and its structural analog plumbagin, are substrates of the multidrug resistance-linked ABC drug transporter ABCG2

Por Shukla, Suneet, Wu, Chung-Pu, Nandigama, Krishnamachary, Ambudkar, Suresh V.
Publicado em 2007

Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp7...

Por Kapoor, Khyati, Bhatnagar, Jaya, Chufan, Eduardo E., Ambudkar, Suresh V.
Publicado em 2013

A Combination of Curcumin with Either Gramicidin or Ouabain Selectively Kills Cells That Express the Multidrug Resistance-linked ABCG2 Transporter

Por Rao, Divya K., Liu, Haiyan, Ambudkar, Suresh V., Mayer, Michael
Publicado no J Biol Chem (2014)

South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy

Por Prasad, N. Rajendra, Muthusamy, Ganesan, Shanmugam, Mohana, Ambudkar, Suresh V.
Publicado no Cancers (Basel) (2016)

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

Por Shukla, Suneet, Abel, Biebele, Chufan, Eduardo E., Ambudkar, Suresh V.
Publicado no J Biol Chem (2017)

Reconstitution of the lysosomal proton pump.

Por D'Souza, M P, Ambudkar, S V, August, J T, Maloney, P C
Publicado em 1987