Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder

Por Arion, Dominique, Corradi, John P., Tang, Shaowu, Datta, Dibyadeep, Boothe, Franklyn, He, Aiqing, Cacace, Angela M., Zaczek, Robert, Albright, Charles F., Tseng, George, Lewis, David A.
Publicado no Mol Psychiatry (2015)

Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes

Por Haas, Laura T., Salazar, Santiago V., Smith, Levi M., Zhao, Helen R., Cox, Timothy O., Herber, Charlotte S., Degnan, Andrew P., Balakrishnan, Anand, Macor, John E., Albright, Charles F., Strittmatter, Stephen M.
Publicado no Cell Rep (2017)

A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat

Por Tong, Gary, Wang, Jun-Sheng, Sverdlov, Oleksandr, Huang, Shu-Pang, Slemmon, Randy, Croop, Robert, Castaneda, Lorna, Gu, Huidong, Wong, Oi, Li, Hewei, Berman, Robert M, Smith, Christina, Albright, Charles F, Dockens, Randy
Publicado em 2013

Characterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease

Por Meredith Jr., Jere E., Sankaranarayanan, Sethu, Guss, Valerie, Lanzetti, Anthony J., Berisha, Flora, Neely, Robert J., Slemmon, J. Randall, Portelius, Erik, Zetterberg, Henrik, Blennow, Kaj, Soares, Holly, Ahlijanian, Michael, Albright, Charles F.
Publicado em 2013

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

Por Small Daniel L, Majumdar Antara, Corradi John, Barrezueta Nestor, Sankaranarayanan Sethu, Meredith Jere E, Guss Valerie, Thompson Mark W, Lin Xu-Alan, Toyn Jeremy H, Hansard Melissa, Lanthorn Thomas, Westphal Ryan S, Albright Charles F
Publicado em 2010-11-01

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

Por Toyn, Jeremy H, Lin, Xu-Alan, Thompson, Mark W, Guss, Valerie, Meredith, Jere E, Sankaranarayanan, Sethu, Barrezueta, Nestor, Corradi, John, Majumdar, Antara, Small, Daniel L, Hansard, Melissa, Lanthorn, Thomas, Westphal, Ryan S, Albright, Charles F
Publicado em 2010

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents

Por Wu, Yong-Jin, Guernon, Jason, Yang, Fukang, Snyder, Lawrence, Shi, Jianliang, Mcclure, Andrea, Rajamani, Ramkumar, Park, Hyunsoo, Ng, Alicia, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Macor, John E., Thompson, Lorin A.
Publicado no ACS Med Chem Lett (2016)

Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models

Por Sankaranarayanan, Sethu, Barten, Donna M., Vana, Laurel, Devidze, Nino, Yang, Ling, Cadelina, Gregory, Hoque, Nina, DeCarr, Lynn, Keenan, Stefanie, Lin, Alan, Cao, Yang, Snyder, Bradley, Zhang, Bin, Nitla, Magdalena, Hirschfeld, Gregg, Barrezueta, Nestor, Polson, Craig, Wes, Paul, Rangan, Vangipuram S., Cacace, Angela, Albright, Charles F., Meredith, Jere, Trojanowski, John Q., Lee, Virginia M-Y., Brunden, Kurt R., Ahlijanian, Michael
Publicado no PLoS One (2015)

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Por Gillman, Kevin W., Starrett, John E., Parker, Michael F., Xie, Kai, Bronson, Joanne J., Marcin, Lawrence R., McElhone, Kate E., Bergstrom, Carl P., Mate, Robert A., Williams, Richard, Meredith, Jere E., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Roberts, Susan B., Lentz, Kimberley A., Houston, John G., Zaczek, Robert, Albright, Charles F., Decicco, Carl P., Macor, John E., Olson, Richard E.
Publicado em 2010

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

Por Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Publicado em 2014

Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

Por Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.
Publicado no J Pharmacol Exp Ther (2016)