Interpreting Alzheimer’s disease clinical trials in light of the effects on amyloid-β

Por Toyn, Jeremy H, Ahlijanian, Michael K
Publicado em 2014

Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae.

Por White, W Hunter, Skatrud, Paul L, Xue, Zhixiong, Toyn, Jeremy H
Publicado em 2003

Swi5 Controls a Novel Wave of Cyclin Synthesis in Late Mitosis

Por Aerne, Birgit L., Johnson, Anthony L., Toyn, Jeremy H., Johnston, Leland H.
Publicado em 1998

γ-Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?

Por Toyn, Jeremy H., Rowley, Adele, Matsuoka, Yasuji, Tomita, Taisuke, Imbimbo, Bruno P.
Publicado em 2013

DBF2 Protein Kinase Binds to and Acts through the Cell Cycle-Regulated MOB1 Protein

Por Komarnitsky, Svetlana I., Chiang, Yueh-Chin, Luca, Francis C., Chen, Junji, Toyn, Jeremy H., Winey, Mark, Johnston, Leland H., Denis, Clyde L.
Publicado em 1998

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

Por Small Daniel L, Majumdar Antara, Corradi John, Barrezueta Nestor, Sankaranarayanan Sethu, Meredith Jere E, Guss Valerie, Thompson Mark W, Lin Xu-Alan, Toyn Jeremy H, Hansard Melissa, Lanthorn Thomas, Westphal Ryan S, Albright Charles F
Publicado em 2010-11-01

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

Por Toyn, Jeremy H, Lin, Xu-Alan, Thompson, Mark W, Guss, Valerie, Meredith, Jere E, Sankaranarayanan, Sethu, Barrezueta, Nestor, Corradi, John, Majumdar, Antara, Small, Daniel L, Hansard, Melissa, Lanthorn, Thomas, Westphal, Ryan S, Albright, Charles F
Publicado em 2010

Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents

Por Wu, Yong-Jin, Guernon, Jason, Yang, Fukang, Snyder, Lawrence, Shi, Jianliang, Mcclure, Andrea, Rajamani, Ramkumar, Park, Hyunsoo, Ng, Alicia, Lewis, Hal, Chang, ChiehYing, Camac, Dan, Toyn, Jeremy H., Ahlijanian, Michael K., Albright, Charles F., Macor, John E., Thompson, Lorin A.
Publicado no ACS Med Chem Lett (2016)

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers

Por Soares, Holly D., Gasior, Maciej, Toyn, Jeremy H., Wang, Jun-Sheng, Hong, Quan, Berisha, Flora, Furlong, Michael T., Raybon, Joseph, Lentz, Kimberley A., Sweeney, Francis, Zheng, Naiyu, Akinsanya, Billy, Berman, Robert M., Thompson, Lorin A., Olson, Richard E., Morrison, John, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Ahlijanian, Michael K., AbuTarif, Malaz
Publicado no J Pharmacol Exp Ther (2016)

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Por Gillman, Kevin W., Starrett, John E., Parker, Michael F., Xie, Kai, Bronson, Joanne J., Marcin, Lawrence R., McElhone, Kate E., Bergstrom, Carl P., Mate, Robert A., Williams, Richard, Meredith, Jere E., Burton, Catherine R., Barten, Donna M., Toyn, Jeremy H., Roberts, Susan B., Lentz, Kimberley A., Houston, John G., Zaczek, Robert, Albright, Charles F., Decicco, Carl P., Macor, John E., Olson, Richard E.
Publicado em 2010

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects

Por Toyn, Jeremy H., Boy, Kenneth M., Raybon, Joseph, Meredith, Jere E., Robertson, Alan S., Guss, Valerie, Hoque, Nina, Sweeney, Francis, Zhuo, Xiaoliang, Clarke, Wendy, Snow, Kimberly, Denton, R. Rex, Zuev, Dmitry, Thompson, Lorin A., Morrison, John, Grace, James, Berisha, Flora, Furlong, Michael, Wang, Jun-Sheng, Lentz, Kimberly A., Padmanabha, Ramesh, Cook, Lynda, Wei, Cong, Drexler, Dieter M., Macor, John E., Albright, Charlie F., Gasior, Maciej, Olson, Richard E., Hong, Quan, Soares, Holly D., AbuTarif, Malaz, Ahlijanian, Michael K.
Publicado no J Pharmacol Exp Ther (2016)

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780

Por Toyn, Jeremy H., Thompson, Lorin A., Lentz, Kimberley A., Meredith, Jere E., Burton, Catherine R., Sankaranararyanan, Sethu, Guss, Valerie, Hall, Tracey, Iben, Lawrence G., Krause, Carol M., Krause, Rudy, Lin, Xu-Alan, Pierdomenico, Maria, Polson, Craig, Robertson, Alan S., Denton, R. Rex, Grace, James E., Morrison, John, Raybon, Joseph, Zhuo, Xiaoliang, Snow, Kimberly, Padmanabha, Ramesh, Agler, Michele, Esposito, Kim, Harden, David, Prack, Margaret, Varma, Sam, Wong, Victoria, Zhu, Yingjie, Zvyaga, Tatyana, Gerritz, Samuel, Marcin, Lawrence R., Higgins, Mendi A., Shi, Jianliang, Wei, Cong, Cantone, Joseph L., Drexler, Dieter M., Macor, John E., Olson, Richard E., Ahlijanian, Michael K., Albright, Charles F.
Publicado em 2014