Passive Immunization with Phospho-Tau Antibodies Reduces Tau Pathology and Functional Deficits in Two Distinct Mouse Tauopathy Models

In Alzheimer’s disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of AD subjects suggests a sequence of initiation and subsequent sprea...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sankaranarayanan, Sethu, Barten, Donna M., Vana, Laurel, Devidze, Nino, Yang, Ling, Cadelina, Gregory, Hoque, Nina, DeCarr, Lynn, Keenan, Stefanie, Lin, Alan, Cao, Yang, Snyder, Bradley, Zhang, Bin, Nitla, Magdalena, Hirschfeld, Gregg, Barrezueta, Nestor, Polson, Craig, Wes, Paul, Rangan, Vangipuram S., Cacace, Angela, Albright, Charles F., Meredith, Jere, Trojanowski, John Q., Lee, Virginia M-Y., Brunden, Kurt R., Ahlijanian, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416899/
https://ncbi.nlm.nih.gov/pubmed/25933020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125614
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