Tau-Directed Drug Discovery for Alzheimer’s Disease and Related Tauopathies: A Focus on Tau Assembly Inhibitors

The microtubule-associated protein tau forms insoluble filaments that deposit as neurofibrillary tangles (NFTs) in the brains of those with Alzheimer’s disease (AD) and other related neurodegenerative disorders. The presence of both NFTs and amyloid β (Aβ)-containing senile plaques within the brain...

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Bibliografiske detaljer
Main Authors: Brunden, Kurt R., Ballatore, Carlo, Crowe, Alex, Smith, Amos B., Lee, Virginia M.-Y., Trojanowski, John Q.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864354/
https://ncbi.nlm.nih.gov/pubmed/19744482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2009.08.031
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