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Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies

The microtubule (MT)-associated protein tau, which is highly expressed in the axons of neurons, is an endogenous MT-stabilizing agent that plays an important role in the axonal transport. Loss of MT-stabilizing tau function, caused by misfolding, hyperphosphorylation and sequestration of tau into in...

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Bibliografische gegevens
Hoofdauteurs: Ballatore, Carlo, Brunden, Kurt R., Huryn, Donna M., Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493881/
https://ncbi.nlm.nih.gov/pubmed/23020671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301079z
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