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Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies
Neurons within the brains of those with AD (Alzheimer’s disease) and related neurodegenerative disorders, collectively termed ‘tauopathies’, contain fibrillar inclusions composed of hyperphosphorylated tau protein. Tau is normally enriched in axons, where it binds and stabilizes MTs (microtubules)....
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3431553/ https://ncbi.nlm.nih.gov/pubmed/22817712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20120010 |
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