Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies

Neurons within the brains of those with AD (Alzheimer’s disease) and related neurodegenerative disorders, collectively termed ‘tauopathies’, contain fibrillar inclusions composed of hyperphosphorylated tau protein. Tau is normally enriched in axons, where it binds and stabilizes MTs (microtubules)....

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Hlavní autoři: Brunden, Kurt R., Ballatore, Carlo, Lee, Virginia M.-Y., Smith, Amos B., Trojanowski, John Q.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431553/
https://ncbi.nlm.nih.gov/pubmed/22817712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20120010
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