Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies

The microtubule (MT)–stabilizing protein tau disengages from MTs and forms intracellular inclusions known as neurofibrillary tangles in Alzheimer’s disease and related tauopathies. Reduced tau binding to MTs in tauopathies may contribute to neuronal dysfunction through decreased MT stabilization and...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Kovalevich, Jane, Cornec, Anne-Sophie, Yao, Yuemang, James, Michael, Crowe, Alexander, Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Amos B., Ballatore, Carlo, Brunden, Kurt R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851320/
https://ncbi.nlm.nih.gov/pubmed/26980057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.231175
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