Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies

The microtubule (MT)–stabilizing protein tau disengages from MTs and forms intracellular inclusions known as neurofibrillary tangles in Alzheimer’s disease and related tauopathies. Reduced tau binding to MTs in tauopathies may contribute to neuronal dysfunction through decreased MT stabilization and...

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Bibliografische gegevens
Gepubliceerd in:J Pharmacol Exp Ther
Hoofdauteurs: Kovalevich, Jane, Cornec, Anne-Sophie, Yao, Yuemang, James, Michael, Crowe, Alexander, Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Amos B., Ballatore, Carlo, Brunden, Kurt R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2016
Onderwerpen:
Drug Discovery and Translational Medicine
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851320/
https://ncbi.nlm.nih.gov/pubmed/26980057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.231175
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