লোডিং...
Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies
The microtubule (MT)–stabilizing protein tau disengages from MTs and forms intracellular inclusions known as neurofibrillary tangles in Alzheimer’s disease and related tauopathies. Reduced tau binding to MTs in tauopathies may contribute to neuronal dysfunction through decreased MT stabilization and...
সংরক্ষণ করুন:
| প্রকাশিত: | J Pharmacol Exp Ther |
|---|---|
| প্রধান লেখক: | , , , , , , , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4851320/ https://ncbi.nlm.nih.gov/pubmed/26980057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.231175 |
| ট্যাগগুলো: |
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