Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies

The microtubule (MT)–stabilizing protein tau disengages from MTs and forms intracellular inclusions known as neurofibrillary tangles in Alzheimer’s disease and related tauopathies. Reduced tau binding to MTs in tauopathies may contribute to neuronal dysfunction through decreased MT stabilization and...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Pharmacol Exp Ther
Asıl Yazarlar: Kovalevich, Jane, Cornec, Anne-Sophie, Yao, Yuemang, James, Michael, Crowe, Alexander, Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Amos B., Ballatore, Carlo, Brunden, Kurt R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2016
Konular:
Drug Discovery and Translational Medicine
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851320/
https://ncbi.nlm.nih.gov/pubmed/26980057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.231175
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller