Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer’s Disease and Related Tauopathies

The microtubule (MT)–stabilizing protein tau disengages from MTs and forms intracellular inclusions known as neurofibrillary tangles in Alzheimer’s disease and related tauopathies. Reduced tau binding to MTs in tauopathies may contribute to neuronal dysfunction through decreased MT stabilization and...

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Detalles Bibliográficos
Publicado en:J Pharmacol Exp Ther
Autores principales: Kovalevich, Jane, Cornec, Anne-Sophie, Yao, Yuemang, James, Michael, Crowe, Alexander, Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Amos B., Ballatore, Carlo, Brunden, Kurt R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2016
Materias:
Drug Discovery and Translational Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851320/
https://ncbi.nlm.nih.gov/pubmed/26980057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.231175
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