טוען...

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

BACKGROUND: Alzheimer’s disease (AD) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. Tau is normally found associated with axonal microtubules (MTs) in the brain, and in tauo...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Mol Neurodegener
Main Authors: Zhang, Bin, Yao, Yuemang, Cornec, Anne-Sophie, Oukoloff, Killian, James, Michael J., Koivula, Pyry, Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo, Brunden, Kurt R.
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223064/
https://ncbi.nlm.nih.gov/pubmed/30404654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0291-3
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