A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

BACKGROUND: Alzheimer’s disease (AD) and related tauopathies are neurodegenerative diseases that are characterized by the presence of insoluble inclusions of the protein tau within brain neurons and often glia. Tau is normally found associated with axonal microtubules (MTs) in the brain, and in tauo...

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Bibliografische gegevens
Gepubliceerd in:Mol Neurodegener
Hoofdauteurs: Zhang, Bin, Yao, Yuemang, Cornec, Anne-Sophie, Oukoloff, Killian, James, Michael J., Koivula, Pyry, Trojanowski, John Q., Smith, Amos B., Lee, Virginia M.-Y., Ballatore, Carlo, Brunden, Kurt R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223064/
https://ncbi.nlm.nih.gov/pubmed/30404654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0291-3
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