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Brain-penetrant, triazolopyrimidine and phenylpyrimidine microtubule-stabilizers as potential leads to treat human African trypanosomiasis
In vitro whole-organism screens of T. brucei with representative examples of brain-penetrant microtubule (MT)-stabilizing agents identified lethal triazolopyrimidines and phenylpyrimidines with sub-μM potency. In mammalian cells, these anti-proliferative compounds disrupt MT-integrity and reduce tot...
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| Udgivet i: | ChemMedChem |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6286711/ https://ncbi.nlm.nih.gov/pubmed/29969537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201800404 |
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