Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines

The [1,2,4]triazolo[1,5-a]pyrimidines comprise a promising class of non-naturally occurring microtubule (MT)-active compounds. Prior studies revealed that different triazolopyrimidine substitutions can yield molecules that either promote MT stabilization or disrupt MT integrity. These differences ca...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Oukoloff, Killian, Kovalevich, Jane, Cornec, Anne-Sophie, Yao, Yuemang, Owyang, Zachary A., James, Michael, Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B., Brunden, Kurt R., Ballatore, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993642/
https://ncbi.nlm.nih.gov/pubmed/29764743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.05.010
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