Discovery of Brain-Penetrant, Orally Bioavailable Aminothienopyridazine Inhibitors of Tau Aggregation

Agents capable of preventing the misfolding and sequestration of the microtubule-stabilizing protein tau into insoluble fibrillar aggregates hold considerable promise for the prevention and/or treatment of neurodegenerative tauopathies such as Alzheimer’s disease. Because tauopathies are characteriz...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Ballatore, Carlo, Brunden, Kurt R., Piscitelli, Francesco, James, Michael J., Crowe, Alex, Yao, Yuemang, Hyde, Edward, Trojanowski, John Q., Lee, Virginia M.-Y., Smith, Amos B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872922/
https://ncbi.nlm.nih.gov/pubmed/20392114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100138f
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