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Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

Alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein Tau. Tau is normally a soluble protein that stabilizes microtubules, with splice isoforms that contain either three (3-R) or four (4-R) microtubule...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Crowe, Alex, James, Michael J., Lee, Virginia M.-Y., Smith, Amos B., Trojanowski, John Q., Ballatore, Carlo, Brunden, Kurt R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630889/
https://ncbi.nlm.nih.gov/pubmed/23443659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436006
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