Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure–activity relationship leads to selection of candidates with desirable in vivo properties

Previous studies demonstrated that members of the aminothienopyridazine (ATPZ) class of tau aggregation inhibitors exhibit a promising combination of in vitro activity as well as favorable pharmacokinetic properties (i.e., brain-penetration and oral bioavailability). Here we report the synthesis and...

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Foilsithe in:Bioorg Med Chem
Main Authors: Ballatore, Carlo, Crowe, Alex, Piscitelli, Francesco, James, Michael, Lou, Kevin, Rossidivito, Gabrielle, Yao, Yuemang, Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R., Smith, Amos B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304654/
https://ncbi.nlm.nih.gov/pubmed/22717239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.027
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