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Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation
Alzheimer disease and several other neurodegenerative disorders are characterized by the accumulation of intraneuronal fibrils comprised of the protein Tau. Tau is normally a soluble protein that stabilizes microtubules, with splice isoforms that contain either three (3-R) or four (4-R) microtubule...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3630889/ https://ncbi.nlm.nih.gov/pubmed/23443659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436006 |
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