Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz.

Por Qin, Jiang-Jiang, Jin, Hui-Zi, Huang, Ying, Zhang, Shou-De, Shan, Lei, Voruganti, Sukesh, Nag, Subhasree, Wang, Wei, Zhang, Wei-Dong, Zhang, Ruiwen
Publicado em 2013

Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents

Por Romagnoli, Romeo, Baraldi, Pier Giovanni, Salvador, Maria Kimatrai, Chayah, Mariem, Camacho, M. Encarnacion, Prencipe, Filippo, Hamel, Ernest, Consolaro, Francesca, Basso, Giuseppe, Viola, Giampietro
Publicado em 2014

Michael Acceptor Approach to the Design of New Salvinorin A-based High Affinity Ligands for the Kappa-Opioid Receptor

Por Polepally, Prabhakar R., Huben, Krzysztof, Vardy, Eyal, Setola, Vincent, Mosier, Philip D., Roth, Bryan L., Zjawiony, Jordan K.
Publicado em 2014

Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus()

Por Saudi, Milind, Zmurko, Joanna, Kaptein, Suzanne, Rozenski, Jef, Neyts, Johan, Van Aerschot, Arthur
Publicado no Eur J Med Chem (2014)

Scaffold hopping approach on the route to selective tankyrase inhibitors

Por Liscio, Paride, Carotti, Andrea, Asciutti, Stefania, Ferri, Martina, Pires, Maira M., Valloscuro, Sara, Ziff, Jacob, Clark, Neil R., Macchiarulo, Antonio, Aaronson, Stuart A., Pellicciari, Roberto, Camaioni, Emidio
Publicado no Eur J Med Chem (2014)

Design and Structure Activity Relationship of Tumor-Homing Histone Deacetylase Inhibitors Conjugated to Folic and Pteroic Acids

Por Sodji, Quaovi H., Kornacki, James R., McDonald, John, Mrksich, Milan, Oyelere, Adegboyega K.
Publicado no Eur J Med Chem (2015)

Synthesis, Molecular Modeling, and Biological Evaluation of Novel RAD51 Inhibitors

Por Zhu, Jiewen, Chen, Hongyuan, Guo, Xuning Emily, Qiu, Xiao-Long, Hu, Chun-Mei, Chamberlin, A. Richard, Lee, Wen-Hwa
Publicado no Eur J Med Chem (2015)

Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase

Por Sari, Ozkan, Roy, Vincent, Métifiot, Mathieu, Marchand, Christophe, Pommier, Yves, Bourg, Stéphane, Bonnet, Pascal, Schinazi, Raymond F., Agrofoglio, Luigi A.
Publicado no Eur J Med Chem (2015)

Potent Multi-target FAAH-COX Inhibitors: Design and Structure-Activity Relationship Studies

Por Migliore, Marco, Habrant, Damien, Sasso, Oscar, Albani, Clara, Bertozzi, Sine Mandrup, Armirotti, Andrea, Piomelli, Daniele, Scarpelli, Rita
Publicado no Eur J Med Chem (2015)

Design, synthesis and biological evaluation of PSMA/hepsin-targeted heterobivalent ligands

Por Subedi, Milan, Minn, Il, Chen, Jianbo, Kim, YunHye, Ok, Kiwon, Jung, Yong Woo, Pomper, Martin G., Byun, Youngjoo
Publicado no Eur J Med Chem (2016)

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach

Por Abadi, Ashraf H., Abouel-Ella, Dalal A., Lehmann, Jochen, Tinsley, Heather N., Gary, Bernard D., Piazza, Gary A., Abdel-Fattah, Mohammed A.O.
Publicado no Eur J Med Chem (2009)

Synthesis and Biological Evaluation of Indole-2-carboxamides Bearing Photoactivatable Functionalities as Novel Allosteric Modulators for the Cannabinoid CB1 Receptor

Por Qiao, Chang-Jiang, Ali, Hamed I., Ahn, Kwang H., Kolluru, Srikanth, Kendall, Debra A., Lu, Dai
Publicado no Eur J Med Chem (2016)

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity

Por Awadallah, Fadi M., Piazza, Gary A., Gary, Bernard D., Keeton, Adam B., Canzoneri, Joshua C.
Publicado no Eur J Med Chem (2013)

Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity

Por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado no Eur J Med Chem (2016)

Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents

Por Carta, Davide, Bortolozzi, Roberta, Sturlese, Mattia, Salmaso, Veronica, Hamel, Ernest, Basso, Giuseppe, Calderan, Laura, Quintieri, Luigi, Moro, Stefano, Viola, Giampietro, Ferlin, Maria Grazia
Publicado no Eur J Med Chem (2016)

Novel anti-inflammatory agents targeting CXCR4: Design, synthesis, biological evaluation and preliminary pharmacokinetic study

Por Bai, Renren, Liang, Zhongxing, Yoon, Younghyoun, Salgado, Eric, Feng, Amber, Gurbani, Saumya, Shim, Hyunsuk
Publicado no Eur J Med Chem (2017)

A unique mid-sequence linker used to multimerize the lipid-phosphatidylserine (PS) binding peptide-peptoid hybrid PPS1

Por Shukla, Satya Prakash, Manarang, Joseph C, Udugamasooriya, D. Gomika
Publicado no Eur J Med Chem (2017)

Design and synthesis of formononetin-dithiocarbamate hybrids that inhibit growth and migration of PC-3 cells via MAPK/Wnt signaling pathways

Por Fu, Dong-Jun, Zhang, Li, Song, Jian, Mao, Ruo-Wang, Zhao, Ruo-Han, Liu, Ying-Chao, Hou, Yu-Hui, Li, Jia-Huan, Yang, Jia-Jia, Jin, Cheng-Yun, Li, Ping, Zi, Xiao-Lin, Liu, Hong-Min, Zhang, Sai-Yang, Zhang, Yan-Bing
Publicado no Eur J Med Chem (2016)

Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells

Por Mendes, Vanessa I. S., Bartholomeusz, Geoffrey A., Ayres, Mary, Gandhi, Varsha, Salvador, Jorge A. R.
Publicado no Eur J Med Chem (2016)

Design and synthesis of novel thiobarbituric acid derivatives targeting both wild-type and BRAF-mutated melanoma cells

Por Ramisetti, Srinivasa Rao, Pandey, Manoj K, Lee, Sang Y., Karelia, Deepkamal, Narayan, Satya, Amin, Shantu, Sharma, Arun K.
Publicado no Eur J Med Chem (2017)