A double whammy – targeting both fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) to treat pain and inflammation

Por Scarpelli, Rita, Sasso, Oscar, Piomelli, Daniele
Publicado no ChemMedChem (2015)

Potent Multi-target FAAH-COX Inhibitors: Design and Structure-Activity Relationship Studies

Por Migliore, Marco, Habrant, Damien, Sasso, Oscar, Albani, Clara, Bertozzi, Sine Mandrup, Armirotti, Andrea, Piomelli, Daniele, Scarpelli, Rita
Publicado no Eur J Med Chem (2015)

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions

Por SASSO, Oscar, BERTORELLI, Rosalia, BANDIERA, Tiziano, SCARPELLI, Rita, COLOMBANO, Giampiero, ARMIROTTI, Andrea, MORENO-SANZ, Guillermo, REGGIANI, Angelo, PIOMELLI, Daniele
Publicado em 2012

Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestina...

Por Sasso, Oscar, Migliore, Marco, Habrant, Damien, Armirotti, Andrea, Albani, Clara, Summa, Maria, Moreno-Sanz, Guillermo, Scarpelli, Rita, Piomelli, Daniele
Publicado no FASEB J (2015)

O-(Triazolyl)methyl carbamates as a novel and potent class of FAAH inhibitors

Por Colombano, Giampiero, Albani, Clara, Ottonello, Giuliana, Ribeiro, Alison, Scarpelli, Rita, Tarozzo, Glauco, Daglian, Jennifer, Jung, Kwang-Mook, Piomelli, Daniele, Bandiera, Tiziano
Publicado no ChemMedChem (2014)

A binding site for non-steroidal anti-inflammatory drugs in FAAH

Por Bertolacci, Laura, Romeo, Elisa, Veronesi, Marina, Magotti, Paola, Albani, Clara, Dionisi, Mauro, Lambruschini, Chiara, Scarpelli, Rita, Cavalli, Andrea, Vivo, Marco De, Piomelli, Daniele, Garau, Gianpiero
Publicado em 2012

Identification and characterization of carprofen as a multi-target FAAH/COX inhibitor

Por Favia, Angelo D., Habrant, Damien, Scarpelli, Rita, Migliore, Marco, Albani, Clara, Bertozzi, Sine Mandrup, Dionisi, Mauro, Tarozzo, Glauco, Piomelli, Daniele, Cavalli, Andrea, De Vivo, Marco
Publicado em 2012

Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain

Por Moreno-Sanz, Guillermo, Barrera, Borja, Armirotti, Andrea, Bertozzi, Sine M., Scarpelli, Rita, Bandiera, Tiziano, Prieto, Julio G., Duranti, Andrea, Tarzia, Giorgio, Merino, Gracia, Piomelli, Daniele
Publicado em 2014

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

Por Bottomley, Matthew J., Lo Surdo, Paola, Di Giovine, Paolo, Cirillo, Agostino, Scarpelli, Rita, Ferrigno, Federica, Jones, Philip, Neddermann, Petra, De Francesco, Raffaele, Steinkühler, Christian, Gallinari, Paola, Carfí, Andrea
Publicado em 2008

Synthesis and Structure-activity Relationship Studies of O-Biphenyl-3-yl Carbamates as Peripherally Restricted Fatty Acid Amide Hydrolase Inhibitors

Por Moreno-Sanz, Guillermo, Duranti, Andrea, Melzig, Laurin, Fiorelli, Claudio, Ruda, Gian Filippo, Colombano, Giampiero, Mestichelli, Paola, Sanchini, Silvano, Tontini, Andrea, Mor, Marco, Bandiera, Tiziano, Scarpelli, Rita, Tarzia, Giorgio, Piomelli, Daniele
Publicado em 2013

Second-generation non-covalent NAAA inhibitors are protective in model of multiple sclerosis

Por Migliore, Marco, Pontis, Silvia, Fuentes de Arriba, Angel Luis, Realini, Natalia, Torrente, Esther, Armirotti, Andrea, Romeo, Elisa, Di Martino, Simona, Russo, Debora, Pizzirani, Daniela, Summa, Maria, Lanfranco, Massimiliano, Ottonello, Giuliana, Busquet, Perrine, Jung, Kwang-Mook, Garcia-Guzman, Miguel, Heim, Roger, Scarpelli, Rita, Piomelli, Daniele
Publicado no Angew Chem Int Ed Engl (2016)