Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain

The blood-brain barrier (BBB) is the main entry route for chemicals into the mammalian central nervous system (CNS). Two transmembrane transporters of the ATP-binding cassette (ABC) family – Breast Cancer Resistance Protein (ABCG2 in humans, Abcg2 in rodents) and P-glycoprotein (ABCB1 in humans, Abc...

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Hauptverfasser: Moreno-Sanz, Guillermo, Barrera, Borja, Armirotti, Andrea, Bertozzi, Sine M., Scarpelli, Rita, Bandiera, Tiziano, Prieto, Julio G., Duranti, Andrea, Tarzia, Giorgio, Merino, Gracia, Piomelli, Daniele
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134960/
https://ncbi.nlm.nih.gov/pubmed/24993496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2014.06.004
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