3–Aminoazetidin–2–one Derivatives as N–Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration

N Acylethanolamine acid amidase (NAAA) is a cysteine hydrolase that catalyzes the hydrolysis of endogenous lipid mediators such as palmitoylethanolamide (PEA). PEA has been shown to exert anti–inflammatory and antinociceptive effects in animals by engaging peroxisome proliferator–activated receptor–...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Fiasella, Annalisa, Nuzzi, Andrea, Summa, Maria, Armirotti, Andrea, Tarozzo, Glauco, Tarzia, Giorgio, Mor, Marco, Bertozzi, Fabio, Bandiera, Tiziano, Piomelli, Daniele
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224963/
https://ncbi.nlm.nih.gov/pubmed/24828120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300546
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