3–Aminoazetidin–2–one Derivatives as N–Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration

N Acylethanolamine acid amidase (NAAA) is a cysteine hydrolase that catalyzes the hydrolysis of endogenous lipid mediators such as palmitoylethanolamide (PEA). PEA has been shown to exert anti–inflammatory and antinociceptive effects in animals by engaging peroxisome proliferator–activated receptor–...

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Bibliografiska uppgifter
I publikationen:ChemMedChem
Huvudupphovsmän: Fiasella, Annalisa, Nuzzi, Andrea, Summa, Maria, Armirotti, Andrea, Tarozzo, Glauco, Tarzia, Giorgio, Mor, Marco, Bertozzi, Fabio, Bandiera, Tiziano, Piomelli, Daniele
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224963/
https://ncbi.nlm.nih.gov/pubmed/24828120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300546
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