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The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system
The O-arylcarbamate URB937 is a potent inhibitor of fatty-acid amide hydrolase (FAAH), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. URB937 is unique among FAAH inhibitors in that is actively extruded from the central nervous system (CNS), and...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3729352/ https://ncbi.nlm.nih.gov/pubmed/21767647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2011.07.001 |
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