Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

Histone deacetylases (HDACs) regulate chromatin status and gene expression, and their inhibition is of significant therapeutic interest. To date, no biological substrate for class IIa HDACs has been identified, and only low activity on acetylated lysines has been demonstrated. Here, we describe inhi...

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Detalhes bibliográficos
Main Authors: Bottomley, Matthew J., Lo Surdo, Paola, Di Giovine, Paolo, Cirillo, Agostino, Scarpelli, Rita, Ferrigno, Federica, Jones, Philip, Neddermann, Petra, De Francesco, Raffaele, Steinkühler, Christian, Gallinari, Paola, Carfí, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258910/
https://ncbi.nlm.nih.gov/pubmed/18614528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803514200
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