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Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase

The synthesis and antiviral evaluation of a series of dihydropyrimidinone and thiopyrimidine derivatives bearing aryl α,γ-diketobutanoic acid moiety are described using the Biginelli multicomponent reaction as key step. The most active among 20 synthesized novel compounds were 4c, 4d and 5b, which p...

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Bibliografski detalji
Izdano u:Eur J Med Chem
Glavni autori: Sari, Ozkan, Roy, Vincent, Métifiot, Mathieu, Marchand, Christophe, Pommier, Yves, Bourg, Stéphane, Bonnet, Pascal, Schinazi, Raymond F., Agrofoglio, Luigi A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629473/
https://ncbi.nlm.nih.gov/pubmed/26451771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.09.015
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