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Synthesis of dihydropyrimidine α,γ-diketobutanoic acid derivatives targeting HIV integrase
The synthesis and antiviral evaluation of a series of dihydropyrimidinone and thiopyrimidine derivatives bearing aryl α,γ-diketobutanoic acid moiety are described using the Biginelli multicomponent reaction as key step. The most active among 20 synthesized novel compounds were 4c, 4d and 5b, which p...
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Izdano u: | Eur J Med Chem |
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Glavni autori: | , , , , , , , , |
Format: | Artigo |
Jezik: | Inglês |
Izdano: |
2015
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Teme: | |
Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629473/ https://ncbi.nlm.nih.gov/pubmed/26451771 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.09.015 |
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