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Biochemical and Pharmacological Analyses of HIV-1 Integrase Flexible Loop Mutants Resistant To Raltegravir
Resistance to raltegravir (RAL), the first HIV-1 integrase (IN) inhibitor approved by the FDA, involves three genetic pathways: IN mutations N155H, Q148H/R/K and Y143H/R/C. Those mutations are generally associated with secondary point mutations. The resulting mutant viruses show high degree of resis...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2866738/ https://ncbi.nlm.nih.gov/pubmed/20334344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100130f |
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