Resultados da pesquisa - ((drug dnaer) OR (drug dna)) ((devel ther) OR (novel ther))

Pesquisas alternativas:
dnaer » dnaee (Expandir a Pesquisa), anaer (Expandir a Pesquisa), dnacr (Expandir a Pesquisa)
devel » level (Expandir a Pesquisa), devem (Expandir a Pesquisa)
ther » them (Expandir a Pesquisa)

1

THER-22. BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL SYNERGISTIC COMBINATIONS WITH ENHANCED SAFETY PROFILES FOR THE TREATMENT OF MEDULLOBLASTOMA AND GLIOBLASTOMA

THER-22. BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL...

Por Lam, Fred C, Vu-Han, Tu-Lan, Van de Kooj, Bert, Kong, Yi Wen, Bandopadhayay, Pratiti, Beroukhim, Rameen, Sarkaria, Jann, Hammond, Paula, Yaffe, Michael
Publicado no Neuro Oncol (2019)

“... of the DNA damage response in cells that allows for the discovery of novel higher order synergistic drug...”
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2

Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin

Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin

Por Guirouilh-Barbat, Josée, Zhang, Yong-Wei, Pommier, Yves
Publicado em 2009

“...Brostallicin is a DNA minor groove binder in Phase II clinical trials. Here we show...”
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3

Insights into novel emerging epigenetic drugs in myeloid malignancies

Insights into novel emerging epigenetic drugs in myeloid malignancies

Por Chandhok, Namrata S., Prebet, Thomas
Publicado no Ther Adv Hematol (2019)

“... chromosome without alterations in the DNA sequence’ and several epigenetic regulators are recurrently mutated...”
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4

Toxoplasma histone acetylation remodelers as novel drug targets

Toxoplasma histone acetylation remodelers as novel drug targets

Por Vanagas, Laura, Jeffers, Victoria, Bogado, Silvina S, Dalmasso, Maria C, Sullivan, William J, Angel, Sergio O
Publicado em 2012

“... facilitate the establishment of a global chromatin environment and orchestrate DNA-related biological...”
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5

ISG15 as a Novel Tumor Biomarker for Drug Sensitivity

ISG15 as a Novel Tumor Biomarker for Drug Sensitivity

Por Desai, Shyamal D., Wood, Laurence M., Tsai, Yu-Chen, Hsieh, Tao-Shih, Marks, Jeffrey R., Scott, Georgia L, Giovanella, Beppino C., Liu, Leroy F.
Publicado em 2008

“... on proteasome-mediated repair of TOP1-DNA covalent complexes. First, shRNA-mediated knockdown of either ISG15...”
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6

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Por Ismail, Mohamed A, Arafa, Reem K, Youssef, Magdy M, El-Sayed, Wael M
Publicado em 2014

“... potent activity, with GI(50) values (drug concentration that causes 50% inhibition of cell growth) from...”
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7

Microdose-induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice

Microdose-induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice

Por Zimmermann, Maike, Wang, Si-Si, Zhang, Hongyong, Lin, Tzu-yin, Malfatti, Michael, Haack, Kurt, Ognibene, Ted, Yang, Hongyuan, Airhart, Susan, Turteltaub, Kenneth W., Cimino, George D., Tepper, Clifford G., Drakaki, Alexandra, Chamie, Karim, de Vere White, Ralph, Pan, Chong-xian, Henderson, Paul T.
Publicado no Mol Cancer Ther (2016)

“... with [(14)C]carboplatin or [(14)C]gemcitabine and the resulting drug-DNA adduct levels were compared...”
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8

In Search of Novel Drug Target Sites on Estrogen Receptors Using RNA Aptamers

In Search of Novel Drug Target Sites on Estrogen Receptors Using RNA Aptamers

Por Xu, Daiying, Chatakonda, Vamsee-Krishna, Kourtidis, Antonis, Conklin, Douglas S., Shi, Hua
Publicado em 2014

“... transcriptional activation in a breast cancer cell line. Serving as a novel drug lead, it may also be used...”
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9

Drug design with Cdc7 kinase: a potential novel cancer therapy target

Drug design with Cdc7 kinase: a potential novel cancer therapy target

Por Sawa, Masaaki, Masai, Hisao
Publicado em 2009

“...Identification of novel molecular targets is critical in development of new and efficient cancer...”
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10

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation

Por Schommer, Nina N., Nguyen, Jacklyn, Yung, Bryan S., Schultheis, Katherine, Muthumani, Kar, Weiner, David B., Humeau, Laurent, Broderick, Kate E., Smith, Trevor R.F.
Publicado no Hum Gene Ther (2019)

“...Plasmid DNA (pDNA) gene delivery is a highly versatile technology that has the potential to address...”
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11

Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer

Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer

Por May FEB
Publicado em 2014-05-01

“..., and palliative control of advanced breast cancer. Next, the potential of novel drugs that target DNA repair...”
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12

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M(4) Muscarinic Receptor as a Novel Therapeutic Target

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M(4) Muscarinic Receptor as a Novel Therapeutic Target

Por Gogliotti, Rocco G., Fisher, Nicole M., Stansley, Branden J., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M.
Publicado no J Pharmacol Exp Ther (2018)

Assuntos: “...Drug Discovery and Translational Medicine...”
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13

A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor

A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor

Por Kerr, Alastair G., Tam, Lawrence C. S., Hale, Ashley B., Cioroch, Milena, Douglas, Gillian, Agkatsev, Sarina, Hibbitt, Olivia, Mason, Joseph, Holt-Martyn, James, Bataille, Carole J. R., Wynne, Graham M., Channon, Keith M., Russell, Angela J., Wade-Martins, Richard
Publicado no J Pharmacol Exp Ther (2017)

Assuntos: “...Drug Discovery and Translational Medicine...”
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14

A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs

A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs

Por Kallen, Karl-Josef, Theß, Andreas
Publicado em 2014

“...Recent advances strongly suggest that mRNA rather than DNA will be the nucleotide basis for a new...”
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15

Therapeutic Effect of Sodium Iodide Symporter Gene Therapy Combined With External Beam Radiotherapy and Targeted Drugs That Inhibit DNA Repair

Therapeutic Effect of Sodium Iodide Symporter Gene Therapy Combined With External Beam Radiotherapy and Targeted Drugs That Inhibit DNA Repair

Por Hingorani, Mohan, White, Christine L, Zaidi, Shane, Pandha, Hardev S, Melcher, Alan A, Bhide, Shreerang A, Nutting, Christopher M, Syrigos, Konstantinos N, Vile, Richard G, Vassaux, Georges, Harrington, Kevin J
Publicado em 2010

“.... In previous studies, we showed that combining NIS gene delivery with external beam radiotherapy (EBRT) and DNA...”
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16

Identification of phosphotyrosine mimetic inhibitors of Human Tyrosyl-DNA Phosphodiesterase I by a novel AlphaScreen high-throughput assay

Identification of phosphotyrosine mimetic inhibitors of Human Tyrosyl-DNA Phosphodiesterase I by a novel AlphaScreen high-throughput assay

Por Marchand, Christophe, Lea, Wendy A., Jadhav, Ajit, Dexheimer, Thomas S, Austin, Christopher P., Inglese, James, Pommier, Yves, Simeonov, Anton
Publicado em 2009

“... natural DNA damage, as well as from the action of certain anticancer drugs. Tdp1 catalyzes the hydrolysis...”
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17

A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Por Asano, Michiyo, Ohyashiki, Junko H, Kobayashi-Kawana, Chiaki, Umezu, Tomohiro, Imanishi, Satoshi, Azuma, Kenko, Akahane, Daigo, Fujimoto, Hiroaki, Ito, Yoshikazu, Ohyashiki, Kazuma
Publicado no Drug Des Devel Ther (2019)

“... patients with myelodysplastic syndrome (MDS). To quantify methylated DNA not only in the promoter region...”
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18

A novel norindeniosoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

A novel norindeniosoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

Por Marchand, Christophe, Antony, Smitha, Kohn, Kurt W., Cushman, Mark, Ioanoviciu, Alexandra, Staker, Bart L., Burgin, Alex B., Stewart, Lance, Pommier, Yves
Publicado em 2006

“... that create hotspots for drug binding. Stabilization of such conformational states results in uncompetitive...”
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19

A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer

A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer

Por Allen, Wendy L., Stevenson, Leanne, Coyle, Vicky M., Jithesh, Puthen V., Proutski, Irina, Carson, Gail, Gordon, Michael A, Lenz, Heinz-Josef D, Van Schaeybroeck, Sandra, Longley, Daniel B., Johnston, Patrick G.
Publicado em 2011

“... to identify novel determinants of resistance to the clinically relevant drugs 5-Fluorouracil (5-FU) and SN38...”
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20

Antiproliferative Activity of Novel Thiopyran Analogs on MCF-7 Breast and HCT-15 Colon Cancer Cells: Synthesis, Cytotoxicity, Cell Cycle Analysis, and DNA-Binding

Antiproliferative Activity of Novel Thiopyran Analogs on MCF-7 Breast and HCT-15 Colon Cancer Cells...

Por Tavakolinia, Fatemeh, Baghipour, Tayebeh, Hossaini, Zinatossadat, Zareyee, Daryoush, Khalilzadeh, Mohammad A., Rajabi, Mehdi
Publicado em 2012

“..., these compounds were found to exhibit significant DNA-binding affinity. Ultraviolet–visible light (UV–Vis...”
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