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In Search of Novel Drug Target Sites on Estrogen Receptors Using RNA Aptamers
Estrogen receptor α (ERα) is a well-validated drug target for a majority of breast cancers. But the target sites on this receptor are far from exhaustively defined. Almost all ER antagonists in clinical use function by binding to the ligand-binding pocket to occlude agonist access. Resistance to thi...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4026216/ https://ncbi.nlm.nih.gov/pubmed/24588102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2013.0474 |
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