A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Purpose: Monitoring response and resistance to 5-azacitidine (AZA) is essential when treating patients with myelodysplastic syndrome (MDS). To quantify methylated DNA not only in the promoter region but also in the gene body, we established a single-molecule methylation assay (SMMA). Patients and me...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Asano, Michiyo, Ohyashiki, Junko H, Kobayashi-Kawana, Chiaki, Umezu, Tomohiro, Imanishi, Satoshi, Azuma, Kenko, Akahane, Daigo, Fujimoto, Hiroaki, Ito, Yoshikazu, Ohyashiki, Kazuma
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553951/
https://ncbi.nlm.nih.gov/pubmed/31239639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S195071
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