A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer

Chemotherapy response rates for advanced colorectal cancer remain disappointingly low, primarily due to drug resistance, so there is an urgent need to improve current treatment strategies. In order to identify novel determinants of resistance to the clinically relevant drugs 5-Fluorouracil (5-FU) an...

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Main Authors: Allen, Wendy L., Stevenson, Leanne, Coyle, Vicky M., Jithesh, Puthen V., Proutski, Irina, Carson, Gail, Gordon, Michael A, Lenz, Heinz-Josef D, Van Schaeybroeck, Sandra, Longley, Daniel B., Johnston, Patrick G.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272421/
https://ncbi.nlm.nih.gov/pubmed/22027693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0510
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