THER-22. BROMODOMAIN INHIBITORS INDUCE DOWNREGULATION OF DNA DAMAGE REPAIR PATHWAYS AND OFFER NOVEL...

Por Lam, Fred C, Vu-Han, Tu-Lan, Van de Kooj, Bert, Kong, Yi Wen, Bandopadhayay, Pratiti, Beroukhim, Rameen, Sarkaria, Jann, Hammond, Paula, Yaffe, Michael
Publicado no Neuro Oncol (2019)

Induction of glutathione-dependent DNA double-strand breaks by the novel anticancer drug brostallicin

Por Guirouilh-Barbat, Josée, Zhang, Yong-Wei, Pommier, Yves
Publicado em 2009

Toxoplasma histone acetylation remodelers as novel drug targets

Por Vanagas, Laura, Jeffers, Victoria, Bogado, Silvina S, Dalmasso, Maria C, Sullivan, William J, Angel, Sergio O
Publicado em 2012

ISG15 as a Novel Tumor Biomarker for Drug Sensitivity

Por Desai, Shyamal D., Wood, Laurence M., Tsai, Yu-Chen, Hsieh, Tao-Shih, Marks, Jeffrey R., Scott, Georgia L, Giovanella, Beppino C., Liu, Leroy F.
Publicado em 2008

Anticancer, antioxidant activities, and DNA affinity of novel monocationic bithiophenes and analogues

Por Ismail, Mohamed A, Arafa, Reem K, Youssef, Magdy M, El-Sayed, Wael M
Publicado em 2014

Microdose-induced Drug-DNA Adducts as Biomarkers of Chemotherapy Resistance in Humans and Mice

Por Zimmermann, Maike, Wang, Si-Si, Zhang, Hongyong, Lin, Tzu-yin, Malfatti, Michael, Haack, Kurt, Ognibene, Ted, Yang, Hongyuan, Airhart, Susan, Turteltaub, Kenneth W., Cimino, George D., Tepper, Clifford G., Drakaki, Alexandra, Chamie, Karim, de Vere White, Ralph, Pan, Chong-xian, Henderson, Paul T.
Publicado no Mol Cancer Ther (2016)

In Search of Novel Drug Target Sites on Estrogen Receptors Using RNA Aptamers

Por Xu, Daiying, Chatakonda, Vamsee-Krishna, Kourtidis, Antonis, Conklin, Douglas S., Shi, Hua
Publicado em 2014

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation

Por Schommer, Nina N., Nguyen, Jacklyn, Yung, Bryan S., Schultheis, Katherine, Muthumani, Kar, Weiner, David B., Humeau, Laurent, Broderick, Kate E., Smith, Trevor R.F.
Publicado no Hum Gene Ther (2019)

Drug design with Cdc7 kinase: a potential novel cancer therapy target

Por Sawa, Masaaki, Masai, Hisao
Publicado em 2009

Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer

Por May FEB
Publicado em 2014-05-01

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M(4) Muscarinic Receptor as a Novel Therapeutic Target

Por Gogliotti, Rocco G., Fisher, Nicole M., Stansley, Branden J., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M.
Publicado no J Pharmacol Exp Ther (2018)

A Genomic DNA Reporter Screen Identifies Squalene Synthase Inhibitors That Act Cooperatively with Statins to Upregulate the Low-Density Lipoprotein Receptor

Por Kerr, Alastair G., Tam, Lawrence C. S., Hale, Ashley B., Cioroch, Milena, Douglas, Gillian, Agkatsev, Sarina, Hibbitt, Olivia, Mason, Joseph, Holt-Martyn, James, Bataille, Carole J. R., Wynne, Graham M., Channon, Keith M., Russell, Angela J., Wade-Martins, Richard
Publicado no J Pharmacol Exp Ther (2017)

A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs

Por Kallen, Karl-Josef, Theß, Andreas
Publicado em 2014

Therapeutic Effect of Sodium Iodide Symporter Gene Therapy Combined With External Beam Radiotherapy and Targeted Drugs That Inhibit DNA Repair

Por Hingorani, Mohan, White, Christine L, Zaidi, Shane, Pandha, Hardev S, Melcher, Alan A, Bhide, Shreerang A, Nutting, Christopher M, Syrigos, Konstantinos N, Vile, Richard G, Vassaux, Georges, Harrington, Kevin J
Publicado em 2010

Identification of phosphotyrosine mimetic inhibitors of Human Tyrosyl-DNA Phosphodiesterase I by a novel AlphaScreen high-throughput assay

Por Marchand, Christophe, Lea, Wendy A., Jadhav, Ajit, Dexheimer, Thomas S, Austin, Christopher P., Inglese, James, Pommier, Yves, Simeonov, Anton
Publicado em 2009

A novel norindeniosoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

Por Marchand, Christophe, Antony, Smitha, Kohn, Kurt W., Cushman, Mark, Ioanoviciu, Alexandra, Staker, Bart L., Burgin, Alex B., Stewart, Lance, Pommier, Yves
Publicado em 2006

A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome

Por Asano, Michiyo, Ohyashiki, Junko H, Kobayashi-Kawana, Chiaki, Umezu, Tomohiro, Imanishi, Satoshi, Azuma, Kenko, Akahane, Daigo, Fujimoto, Hiroaki, Ito, Yoshikazu, Ohyashiki, Kazuma
Publicado no Drug Des Devel Ther (2019)

A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer

Por Allen, Wendy L., Stevenson, Leanne, Coyle, Vicky M., Jithesh, Puthen V., Proutski, Irina, Carson, Gail, Gordon, Michael A, Lenz, Heinz-Josef D, Van Schaeybroeck, Sandra, Longley, Daniel B., Johnston, Patrick G.
Publicado em 2011

Antiproliferative Activity of Novel Thiopyran Analogs on MCF-7 Breast and HCT-15 Colon Cancer Cells...

Por Tavakolinia, Fatemeh, Baghipour, Tayebeh, Hossaini, Zinatossadat, Zareyee, Daryoush, Khalilzadeh, Mohammad A., Rajabi, Mehdi
Publicado em 2012

Establishment of stable Huh-7 cell lines expressing various hepatitis C virus genotype 3a protein: an in-vitro testing system for novel anti-HCV drugs

Por Butt, Sadia, Idrees, Muhammad, Rehman, Irshad-ur, Ali, Liaqat, Hussain, Abrar, Ali, Muhammad, Ahmed, Naveed, Saleem, Sana, Fayyaz, Madiha
Publicado em 2011