Resultados da pesquisa - (( drug dna develop type ) or ( drug doses develop type ))

Pesquisas alternativas:
doses develop » loss develop (Expandir a Pesquisa), models develop (Expandir a Pesquisa), locus develop (Expandir a Pesquisa)
develop type » developing type (Expandir a Pesquisa)
dna develop » a develop (Expandir a Pesquisa), 133a develop (Expandir a Pesquisa), cd38 develop (Expandir a Pesquisa)
drug doses » drug dose (Expandir a Pesquisa), drug disease (Expandir a Pesquisa)

21

Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours

Por Mellinas-Gomez, Maria, Spanswick, Victoria J., Paredes-Moscosso, Solange R., Robson, Matthew, Pedley, R. Barbara, Thurston, David E., Baines, Stephen J., Stell, Anneliese, Hartley, John A.
Publicado no BMC Vet Res (2015)

“.... There is clearly a need to develop more effective anti-cancer drugs in dogs. SG2000 (SJG-136) is a sequence...”
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22

Protective effect of Nigella sativa and thymoquinone on serum/glucose deprivation-induced DNA damage in PC12 cells

Protective effect of Nigella sativa and thymoquinone on serum/glucose deprivation-induced DNA damage in PC12 cells

Por Babazadeh, Beheshteh, Sadeghnia, Hamid Reza, Safarpour Kapurchal, Elham, Parsaee, Heydar, Nasri, Sima, Tayarani-Najaran, Zahra
Publicado em 2012

“... of the molecular mechanisms of neuronal damage during ischemia and for the development of neuroprotective drugs...”
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23

Tenuifolide B from Cinnamomum tenuifolium Stem Selectively Inhibits Proliferation of Oral Cancer Cells via Apoptosis, ROS Generation, Mitochondrial Depolarization, and DNA Damage

Tenuifolide B from Cinnamomum tenuifolium Stem Selectively Inhibits Proliferation of Oral Cancer Cells via Apoptosis, ROS Generation, Mitochondrial Depolarization, and DNA Damage

Por Chen, Chung-Yi, Yen, Ching-Yu, Wang, Hui-Ru, Yang, Hui-Ping, Tang, Jen-Yang, Huang, Hurng-Wern, Hsu, Shih-Hsien, Chang, Hsueh-Wei
Publicado no Toxins (Basel) (2016)

“...The development of drugs that selectively kill oral cancer cells but are less harmful to normal...”
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24

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts

Por Donejko M, Przylipiak A, Rysiak E, Miltyk W, Galicka E, Przylipiak J, Zaręba I, Surazynski A
Publicado em 2015-11-01

“...Drug Design, Development and Therapy...”
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25

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Synthesis, antimicrobial, and antiproliferative activities of substituted phenylfuranylnicotinamidines

Por Youssef MM, Arafa RK, Ismail MA
Publicado em 2016-03-01

“...Drug Design, Development and Therapy...”
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26

Identification of Mitoxantrone as a TRAIL-sensitizing agent for Glioblastoma Multiforme

Identification of Mitoxantrone as a TRAIL-sensitizing agent for Glioblastoma Multiforme

Por Senbabaoglu, Filiz, Cingoz, Ahmet, Kaya, Ezgi, Kazancioglu, Selena, Lack, Nathan A., Acilan, Ceyda, Bagci-Onder, Tugba
Publicado no Cancer Biol Ther (2016)

“... response without any effect on their own. One such drug, Mitoxantrone, a DNA-damaging agent, did not cause...”
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27

In search of a selective antiviral chemotherapy.

In search of a selective antiviral chemotherapy.

Por De Clercq, E
Publicado em 1997

“...-bromovinyl)-2'-deoxyuridine (BVDU [brivudin]) for the therapy of herpes simplex virus type 1 and varicella...”
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28

Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone

Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone

Por Gonçalves, António Pedro, Máximo, Valdemar, Lima, Jorge, Singh, Keshav K., Soares, Paula, Videira, Arnaldo
Publicado em 2011

“... with the drug for a longer period become senescent. Treatment of mtDNA-depleted cells with rotenone induces cell...”
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29

A theoretical quantitative model for evolution of cancer chemotherapy resistance

A theoretical quantitative model for evolution of cancer chemotherapy resistance

Por Gatenby Robert A, Silva Ariosto S
Publicado em 2010-04-01

“... to these drugs ultimately resulting in treatment failure and cancer progression. Causes for chemotherapy failure...”
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30

Isogenic Strain Construction and Gene Targeting in Candida dubliniensis

Isogenic Strain Construction and Gene Targeting in Candida dubliniensis

Por Staib, Peter, Moran, Gary P., Sullivan, Derek J., Coleman, David C., Morschhäuser, Joachim
Publicado em 2001

“... of the drug benomyl strongly activated the reporter gene fusion in a dose-dependent fashion, demonstrating...”
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31

Effective implementation of novel MET pharmacodynamic assays in translational studies

Effective implementation of novel MET pharmacodynamic assays in translational studies

Por Srivastava, Apurva K., Navas, Tony, Herrick, William G., Hollingshead, Melinda G., Bottaro, Donald P., Doroshow, James H., Parchment, Ralph E.
Publicado no Ann Transl Med (2017)

“... over 20 years of drug development to target MET in cancers, a pure anti-MET therapeutic has not yet...”
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32

Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial Agents

Por Singh, Sheo B., Kaelin, David E., Wu, Jin, Miesel, Lynn, Tan, Christopher M., Meinke, Peter T., Olsen, David, Lagrutta, Armando, Bradley, Prudence, Lu, Jun, Patel, Sangita, Rickert, Keith W., Smith, Robert F., Soisson, Stephen, Wei, Changqing, Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Fukuda, Yasumichi
Publicado em 2014

“... necessitating the discovery of new agents. Bacterial type II topoisomerase is a clinically validated, highly...”
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33

A theoretical quantitative model for evolution of cancer chemotherapy resistance

A theoretical quantitative model for evolution of cancer chemotherapy resistance

Por Silva, Ariosto S, Gatenby, Robert A
Publicado em 2010

“..., and phenotypic resistance to drug-induced toxicity through upregulated xenobiotic metabolism or DNA repair...”
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34

Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model

Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model

Por Jingmin Zhang, Yafeng Wang, Youmei Peng, Chongzhen Qin, Yixian Liu, Jingjing Li, Jinhua Jiang, Yubing Zhou, Junbiao Chang, Qingduan Wang
Publicado em 2018-11-01

“... showed that NCC inhibited DNA replication and HBeAg production in wild-type or lamivudine-resistant HBV...”
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35

Differential effects of acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine on herpes simplex virus and Epstein-Barr virus in a dually infected human lymphoblastoid cell line.

Differential effects of acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine on herpes simplex virus and Epstein-Barr virus in a dually infected human lymphoblastoid cell line.

Por van der Horst, C M, Lin, J C, Raab-Traub, N, Smith, M C, Pagano, J S
Publicado em 1987

“... drugs suppressed HSV replication in a dose-related manner. In the continued presence of the drugs, HSV...”
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36

Xenobiotic Effects on Ovarian Preantral Follicles

Xenobiotic Effects on Ovarian Preantral Follicles

Por Mark-Kappeler, Connie J., Hoyer, Patricia B., Devine, Patrick J.
Publicado em 2011

“.... Effects depend on dose, type, and reactivity of the drug, and the age of the individual. Evidence suggests...”
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37

SeMet attenuates OTA-induced PCV2 replication promotion by inhibiting autophagy by activating the AKT/mTOR signaling pathway

SeMet attenuates OTA-induced PCV2 replication promotion by inhibiting autophagy by activating the AKT/mTOR signaling pathway

Por Gang Qian, Dandan Liu, Junfa Hu, Fang Gan, Lili Hou, Nianhui Zhai, Xingxiang Chen, Kehe Huang
Publicado em 2018-02-01

“... infections and autophagy may be a potential marker to develop novel anti-PCV2 drugs....”
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38

Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours

Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours

Por Hussein, D, Holt, S V, Brookes, K E, Klymenko, T, Adamski, J K, Hogg, A, Estlin, E J, Ward, T, Dive, C, Makin, G W J
Publicado em 2009

“... problematic for several paediatric tumour types. The urgent need to access novel agents to treat drug...”
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39

Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α

Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α

Por Kim, Yeo-Jung, Lee, Hae-June, Kim, Tae-Min, Eisinger-Mathason, TS Karin, Zhang, Alexia Y, Schmidt, Benjamin, Karl, Daniel L, Nakazawa, Michael S, Park, Peter J, Simon, M Celeste, Yoon, Sam S
Publicado em 2013

“... chemotherapeutic drug for sarcomas, doxorubicin (Dox), was recently found to block HIF-1α binding to DNA at low...”
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40

Azathioprine induction of tumors with microsatellite instability: Risk evaluation using a mouse model

Azathioprine induction of tumors with microsatellite instability: Risk evaluation using a mouse model

Por Bodo, Sahra, Svrcek, Magali, Sourrouille, Isabelle, Cuillières-Dartigues, Peggy, Ledent, Tatiana, Dumont, Sylvie, Dinard, Laetitia, Lafitte, Philippe, Capel, Camille, Collura, Ada, Buhard, Olivier, Wanherdrick, Kristell, Chalastanis, Alexandra, Penard-Lacronique, Virginie, Fabiani, Bettina, Fléjou, Jean-François, Brousse, Nicole, Beaugerie, Laurent, Duval, Alex, Muleris, Martine
Publicado no Oncotarget (2015)

“... they escape apoptosis resulting from MMR-dependent signaling of drug-induced DNA damage. Prolonged treatment...”
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