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Azathioprine induction of tumors with microsatellite instability: Risk evaluation using a mouse model

Mismatch-repair (MMR)-deficient cells show increased in vitro tolerance to thiopurines because they escape apoptosis resulting from MMR-dependent signaling of drug-induced DNA damage. Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested a...

詳細記述

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書誌詳細
出版年:Oncotarget
主要な著者: Bodo, Sahra, Svrcek, Magali, Sourrouille, Isabelle, Cuillières-Dartigues, Peggy, Ledent, Tatiana, Dumont, Sylvie, Dinard, Laetitia, Lafitte, Philippe, Capel, Camille, Collura, Ada, Buhard, Olivier, Wanherdrick, Kristell, Chalastanis, Alexandra, Penard-Lacronique, Virginie, Fabiani, Bettina, Fléjou, Jean-François, Brousse, Nicole, Beaugerie, Laurent, Duval, Alex, Muleris, Martine
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694807/
https://ncbi.nlm.nih.gov/pubmed/26327213
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