Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α

Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, t...

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Detalhes bibliográficos
Main Authors: Kim, Yeo-Jung, Lee, Hae-June, Kim, Tae-Min, Eisinger-Mathason, TS Karin, Zhang, Alexia Y, Schmidt, Benjamin, Karl, Daniel L, Nakazawa, Michael S, Park, Peter J, Simon, M Celeste, Yoon, Sam S
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2013
Assuntos:
Cancer Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677782/
https://ncbi.nlm.nih.gov/pubmed/22684860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27666
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