Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis

Genetic aberrations responsible for soft-tissue sarcoma formation in adults are largely unknown, with targeted therapies sorely needed for this complex and heterogeneous family of diseases. Here we report that that the Hippo pathway is deregulated in many soft-tissue sarcomas, resulting in elevated...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Eisinger-Mathason, T. S. Karin, Mucaj, Vera, Biju, Kevin M., Nakazawa, Michael S., Gohil, Mercy, Cash, Timothy P., Yoon, Sam S., Skuli, Nicolas, Park, Kyung Min, Gerecht, Sharon, Simon, M. Celeste
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4491775/
https://ncbi.nlm.nih.gov/pubmed/26080399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420005112
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