Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis

Intratumoral hypoxia and expression of Hypoxia Inducible Factor 1α (HIF1α) correlate with metastasis and poor survival in sarcoma patients. We demonstrate here that hypoxia controls sarcoma metastasis through a novel mechanism wherein HIF1α enhances expression of the intracellular enzyme procollagen...

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Detaylı Bibliyografya
Asıl Yazarlar: Eisinger-Mathason, T.S. Karin, Zhang, Minsi, Qiu, Qiong, Skuli, Nicolas, Nakazawa, Michael S., Karakasheva, Tatiana, Mucaj, Vera, Shay, Jessica E.S., Stangenberg, Lars, Sadri, Navid, Puré, Ellen, Yoon, Sam S., Kirsch, David G., Simon, M. Celeste
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822914/
https://ncbi.nlm.nih.gov/pubmed/23906982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0118
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