Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis

Intratumoral hypoxia and expression of Hypoxia Inducible Factor 1α (HIF1α) correlate with metastasis and poor survival in sarcoma patients. We demonstrate here that hypoxia controls sarcoma metastasis through a novel mechanism wherein HIF1α enhances expression of the intracellular enzyme procollagen...

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Autors principals: Eisinger-Mathason, T.S. Karin, Zhang, Minsi, Qiu, Qiong, Skuli, Nicolas, Nakazawa, Michael S., Karakasheva, Tatiana, Mucaj, Vera, Shay, Jessica E.S., Stangenberg, Lars, Sadri, Navid, Puré, Ellen, Yoon, Sam S., Kirsch, David G., Simon, M. Celeste
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822914/
https://ncbi.nlm.nih.gov/pubmed/23906982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0118
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