Inhibition of vascular endothelial growth factor A and hypoxia inducible factor 1α maximize the effects of radiation in sarcoma mouse models through destruction of tumor vasculature

PURPOSE: Human sarcomas with a poor response to radiation therapy (RT) and vascular endothelial growth factor A (VEGF-A) inhibition have upregulation of hypoxia inducible factor 1α (HIF-1α) and HIF-1α target genes. This study examines the addition of genetic or pharmacologic inhibition of HIF-1α to...

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Détails bibliographiques
Publié dans:Int J Radiat Oncol Biol Phys
Auteurs principaux: Lee, Hae-June, Yoon, Changhwan, Park, Do Joong, Kim, Yeo-Jung, Schmidt, Benjamin, Lee, Yoon-Jin, Tap, William D., Eisinger-Mathason, T.S. Karin, Choy, Edwin, Kirsch, David G., Simon, M. Celeste, Yoon, Sam S.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559849/
https://ncbi.nlm.nih.gov/pubmed/25544668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2014.10.047
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