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Inhibition of vascular endothelial growth factor A and hypoxia inducible factor 1α maximize the effects of radiation in sarcoma mouse models through destruction of tumor vasculature
PURPOSE: Human sarcomas with a poor response to radiation therapy (RT) and vascular endothelial growth factor A (VEGF-A) inhibition have upregulation of hypoxia inducible factor 1α (HIF-1α) and HIF-1α target genes. This study examines the addition of genetic or pharmacologic inhibition of HIF-1α to...
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| Udgivet i: | Int J Radiat Oncol Biol Phys |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4559849/ https://ncbi.nlm.nih.gov/pubmed/25544668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2014.10.047 |
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